{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:25:39Z","timestamp":1753356339528,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone. &lt;b&gt;&lt;i&gt;Cases:&lt;\/i&gt;&lt;\/b&gt; Two patients with 360 degrees of limbal involvement. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Two patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Thorough examination and multiple biopsies excluded invasive disease. The patients had complete response to therapy. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Widespread intraepithelial squamous neoplasia involving the entire limbus can be successfully treated with topical therapies. Biopsy plays a role in excluding invasive disease. Interferon alpha-2b is a preferable agent to start with because it is well tolerated. Since long-term risks of recurrence are unknown, appropriate monitoring is essential.<\/jats:p>","DOI":"10.1159\/000486339","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T22:01:30Z","timestamp":1518559290000},"page":"298-303","source":"Crossref","is-referenced-by-count":4,"title":["Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b"],"prefix":"10.1159","volume":"4","author":[{"given":"Hershel","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren\u00a0J.","family":"Jeang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar\u00a0M.","family":"Espana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis\u00a0E.","family":"Margo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.1997.tb01514.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.02.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/16207.6791"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/16207.6791"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.04.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.07.026"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.160820"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01569-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.0365"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150810025"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.02.034"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73072-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090210029007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.11.035"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.185620"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4103\/2008-322X.150811"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.62"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12377"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.05.058"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182523f61"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.10.039"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.08.028"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2017.01.009"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.10.048"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.03.045"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.10.043"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.195010"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12300"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.10.012"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30287-5"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:33:09Z","timestamp":1745425989000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,9,6]]},"published-print":{"date-parts":[[2018,9,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000486339","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"type":"print","value":"2296-4681"},{"type":"electronic","value":"2296-4657"}],"subject":[],"published":{"date-parts":[[2018]]}}}