{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:14:08Z","timestamp":1788383648612,"version":"build-2803163510"},"reference-count":24,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":2959,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The effects of chronic lymphocytic thyroiditis (CLT) on the presentation and outcome of papillary thyroid carcinoma (PTC) have long been a topic of controversy. Objective: To evaluate the effect of coexistent CLT on the clinicopathological features of PTC. Design: Retrospective study. Patients: All patients with PTC who had been followed by the 2 co-investigators (Juan Rivera and Richard J. Payne) between 2006 and 2011 were included. Results: CLT was present in 35% (166) of the included patients and was associated with a higher proportion of patients with TNM stage I (p = 0.027) and fewer patients with persistent disease (p = 0.014) in comparison with the PTC-only group. Analysis of the data based on age (&amp;lt;45 or &amp;gt;45 years) revealed that in the older group, the presence of CLT was associated with fewer patients with persistent disease (p = 0.03) and capsular invasion (p = 0.05). However, in patients &amp;lt;45 years of age, the presence of CLT was associated with more capsular invasion (p = 0.003) and extrathyroidal extension (p = 0.004) compared with the PTC-only group. Conclusions: CLT in patients with PTC was associated with lower-stage disease and less disease persistence in patients &amp;gt;45 years of age. In patients &amp;lt;45 years, the presence of CLT appeared to be associated with unfavorable pathological features.<\/jats:p>","DOI":"10.1159\/000486367","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T17:01:37Z","timestamp":1515603697000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":41,"title":["Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer"],"prefix":"10.1530","volume":"7","author":[{"given":"Saleha","family":"Babli","sequence":"first","affiliation":[{"name":"1Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Qu\u00e9bec, Canada"},{"name":"2Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard\u00a0J.\u00a0","family":"Payne","sequence":"additional","affiliation":[{"name":"3Department of Otolaryngology, Royal Victoria Hospital, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Mitmaker","sequence":"additional","affiliation":[{"name":"4Department of Surgery, Montreal General Hospital, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rivera","sequence":"additional","affiliation":[{"name":"1Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"2026070712503730300_ref1","doi-asserted-by":"crossref","unstructured":"Robbins J, Merino MJ, Boice JD Jr, Ron E, Ain KB, Alexander HR, Norton JA, Reynolds J: Thyroid cancer: a lethal endocrine neoplasm. Ann Intern Med 1991; 115: 133\u2013147.","DOI":"10.7326\/0003-4819-115-2-133"},{"key":"2026070712503730300_ref2","doi-asserted-by":"crossref","unstructured":"Ain KB: Papillary thyroid carcinoma. Etiology, assessment, and therapy. Endocrinol Metab Clin North Am 1995; 24: 711\u2013760.","DOI":"10.1016\/S0889-8529(18)30020-3"},{"key":"2026070712503730300_ref3","doi-asserted-by":"crossref","unstructured":"Hodgson NC, Button J, Solorzano CC: Thyroid cancer: is the incidence still increasing? Ann Surg Oncol 2004; 11: 1093\u20131097.","DOI":"10.1245\/ASO.2004.03.066"},{"key":"2026070712503730300_ref4","doi-asserted-by":"crossref","unstructured":"Daily ME, Lindsay S, Skahen R: Relation of thyroid neoplasm to Hashimoto\u2019s disease of the thyroid gland. AMA Arch Surg 1955; 70: 291\u2013297.","DOI":"10.1001\/archsurg.1955.01270080137023"},{"key":"2026070712503730300_ref5","doi-asserted-by":"crossref","unstructured":"Kashima K, Yokoyama S, Noguchi S, Murakami N, Yamashita H, Watanabe S, Uchino S, Toda M, Sasaki A, Daa T, Nakayama I: Chronic thyroiditis as a favorable prognosis factor in PTC. Thyroid 1998; 8: 197\u2013202.","DOI":"10.1089\/thy.1998.8.197"},{"key":"2026070712503730300_ref6","doi-asserted-by":"crossref","unstructured":"Matsubayashi S, Kawai K, Matsumoto Y, Mukuta T, Morita T, Hirai K, Matsuzuka F, Kakudoh K, Kuma K, Tamai H: The correlation between papillary thyroid carcinoma and lymphocytic infiltration of the thyroid. J Clin Endocrinol Metab 1995; 80: 3421\u20133424.","DOI":"10.1210\/jcem.80.12.8530576"},{"key":"2026070712503730300_ref7","doi-asserted-by":"crossref","unstructured":"Antonaci A, Consorti F, Mardente S, Giovannone G: Clinical and biological relationship between chronic lymphocytic thyroiditis and papillary thyroid cancer. Oncol Res 2009; 17: 495\u2013503.","DOI":"10.3727\/096504009789735431"},{"key":"2026070712503730300_ref8","doi-asserted-by":"crossref","unstructured":"Loh KC, Greenspan FS, Dong F, Miller TR, Yeo PP: Influence of lymphocytic thyroiditis on the prognostic outcome of patients with PTC. J Clin Endocrinol Metab 1999; 84: 458\u2013463.","DOI":"10.1210\/jcem.84.2.5443"},{"key":"2026070712503730300_ref9","doi-asserted-by":"crossref","unstructured":"Meier DW, Woolner LB, Beahrs OH, McConahey WM: Parenchymal findings in thyroid carcinoma: pathologic study of 256 cases. J Clin Endocrinol Metab 1959; 19: 162\u2013171.","DOI":"10.1210\/jcem-19-1-162"},{"key":"2026070712503730300_ref10","doi-asserted-by":"crossref","unstructured":"Kebebew E, Treseler PA, Ituarte PH, Clark OH: Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg 2001; 25: 632\u2013637.","DOI":"10.1007\/s002680020165"},{"key":"2026070712503730300_ref11","doi-asserted-by":"crossref","unstructured":"Bie-yu H, Chuen H, Tzu- Chieh C: Well differentiated thyroid carcinoma with concomitant Hashimoto\u2019s thyroiditis present with less aggressive clinical stage and low recurrence rate. Endocr Pathol 2011; 22: 144\u2013149.","DOI":"10.1007\/s12022-011-9164-9"},{"key":"2026070712503730300_ref12","doi-asserted-by":"crossref","unstructured":"Singh B, Shaha AR, Trivedi H, Carew JF, Poluri A, Shah JP: Coexistent Hashimoto\u2019s thyroiditis with papillary thyroid carcinoma: impact on presentation, management and outcome. Surgery 1999; 126: 1070\u20131076.","DOI":"10.1067\/msy.2099.101431"},{"key":"2026070712503730300_ref13","doi-asserted-by":"crossref","unstructured":"Del Rio P, Cataldo S, Sommaruga L, Concione L, Arcuri MF, Sianesi M: The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer? Minerva Endocrinol 2008; 33: 1\u20135.","DOI":"10.1159\/000127404"},{"key":"2026070712503730300_ref14","doi-asserted-by":"crossref","unstructured":"Copper D, Doherty G, Haugen B, Kloos R, Lee S, Mandel S, Mazzaferri E, Mclver B, Sherman B, Tuttle M: Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2006; 16: 109\u2013142.","DOI":"10.1089\/thy.2006.16.109"},{"key":"2026070712503730300_ref15","doi-asserted-by":"crossref","unstructured":"American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper D, Doherty G, Haugen B, Kloos R, Lee S, Mandel S, Mazzaferri E, McIver B, Pacini F, Schlumberger M, Sherman I, Steward L, Tuttle M: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009; 19: 1167\u20131214.","DOI":"10.1089\/thy.2009.0110"},{"key":"2026070712503730300_ref16","doi-asserted-by":"crossref","unstructured":"Verburg FA, Luster M, Cupini C, Chiovato L, Duntas L, Elisei R, Feldt-Rasmussen Rimmel H, Seregni E, Smit JW, Theimer C, Giovanella L: 2013 implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer. Thyroid 2013; 23: 1211\u20131225.","DOI":"10.1089\/thy.2012.0606"},{"key":"2026070712503730300_ref17","doi-asserted-by":"crossref","unstructured":"Braverman LE: Iodine and thyroid: 33 years of study. Thyroid 1994; 4: 351\u2013356.","DOI":"10.1089\/thy.1994.4.351"},{"key":"2026070712503730300_ref18","doi-asserted-by":"crossref","unstructured":"Ahn D, Heo SJ, Park JH, Kim JH, Sohn JH, Park JY, Park SK, Park J: Clinical relationship between Hashimoto\u2019s thyroiditis and papillary thyroid cancer. Acta Oncol 2011; 50: 1228\u20131234.","DOI":"10.3109\/0284186X.2011.602109"},{"key":"2026070712503730300_ref19","doi-asserted-by":"crossref","unstructured":"Giordano C, Stassi G, De Maria R, Todaro M, Richiusa P, Papoff G, Ruberti G, Bagnasco M, Testi R, Galluzzo A: Potential involvement of FAS and its ligand in the pathogenesis of Hashimoto\u2019s thyroiditis. Science 1997; 275: 960\u2013963.","DOI":"10.1126\/science.275.5302.960"},{"key":"2026070712503730300_ref20","doi-asserted-by":"crossref","unstructured":"Kimura H, Yamashita S, Namba H, Tominaga T, Tsuruta M, Yokoyama N, Izumi M, Naga\u00adtaki S: Interleukin-1 inhibits thyroid carcinoma cell growth. J Clin Endocrinol Metab 1992; 75: 596\u2013602.","DOI":"10.1210\/jcem.75.2.1322431"},{"key":"2026070712503730300_ref21","doi-asserted-by":"crossref","unstructured":"Kim SK, Song KH, Lim SD, Lim YC, Yoo YB, Kim JS, Hwang TS: Clinical and pathological features and BRAF mutation in patients with papillary thyroid carcinoma with and without concurrent Hashimoto thyroiditis. Thyroid 2009; 19: 137\u2013141.","DOI":"10.1089\/thy.2008.0144"},{"key":"2026070712503730300_ref22","doi-asserted-by":"crossref","unstructured":"Muzza M, Degl\u2019Innocenti D, Colombo C, Perrino M, Ravasi E, Rossi S, et al: The tight relationship between papillary thyroid cancer autoimmunity and inflammation: clinical and molecular studies. Clin Endocrinol 2010; 72: 702\u2013708.","DOI":"10.1111\/j.1365-2265.2009.03699.x"},{"key":"2026070712503730300_ref23","doi-asserted-by":"crossref","unstructured":"Rotondi M, Coperchini F, Chiovato L: CXCL8 in thyroid disease: from basic notions to potential applications in clinical practice. Cytokine Growth Factor Rev 2013; 24: 539\u2013546.","DOI":"10.1016\/j.cytogfr.2013.08.001"},{"key":"2026070712503730300_ref24","doi-asserted-by":"crossref","unstructured":"Cunha LL, Morari EC, Guihen AC, Razolli D, Gerhard R, Nonogaki S, Soares FA, Vassallo J, Ward LS: Infiltration of a mixture&lt;bold&gt;&lt;\/bold&gt; of immune cells may be related to good prognosis in patients with differentiated thyroid carcinoma. 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