{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:31:57Z","timestamp":1761197517214,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The burden of mild (i.e., subclinical) tremor within essential tremor (ET) families is not fully understood. We assessed the burden of mild tremor in a cohort of 287 adults, none of whom reported tremor or were diagnosed with ET. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We recruited adults in 2 groups based on the familial risk for ET: 244 high-risk individuals (i.e., reporting one or more first-degree relative with ET) and 43 low-risk individuals (i.e., reporting no relatives with ET). Tremor was objectively assessed on 4 hand-drawn spirals (total spiral score\u00a0= 0\u201312). Mild tremor was defined using 3 different cut points. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The prevalence rates of mild tremor among high-risk individuals ranged from 41.4 to 98.4% and were highly dependent on the cut point. Above a certain threshold (i.e., a total spiral score \u22655), 1-in-5 (i.e., 19.7%) high-risk individuals exhibited mild tremor, whereas no low-risk individuals did. High-risk individuals were 3.09\u20134.50 times more likely than low-risk individuals to exhibit mild tremor. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The burden of ET extends beyond the boundaries of the clinically defined disease, and partially expressed forms of ET are abundant in ET families. This fact greatly complicates gene-finding studies and epidemiological studies whose goal is to detect disease-linked associations.<\/jats:p>","DOI":"10.1159\/000486485","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T22:01:27Z","timestamp":1516140087000},"page":"41-46","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Burden of Subclinical Tremor in a Cohort of Normal Individuals Stratified by Familial Risk for Essential Tremor"],"prefix":"10.1159","volume":"50","author":[{"given":"Elan\u00a0D.","family":"Louis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James\u00a0H.","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunmilayo\u00a0M.","family":"Badejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley\u00a0D.","family":"Cristal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruby","family":"Hickman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pam","family":"Factor-Litvak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23284"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000099075.19951.8C"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7916\/D89P30BB"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10376"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.4.805"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7916\/D8Q23Z0Z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1022"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000348553"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7916\/D8KK9C8Q"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.10.1584"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.01.021"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.7916\/D8KW5MRG"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1351"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7916\/D8QZ28QP"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20915"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000442576"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02875.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000371850"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:34:24Z","timestamp":1745426064000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":18,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2018,3,20]]},"published-print":{"date-parts":[[2018,3,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000486485","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"type":"print","value":"0251-5350"},{"type":"electronic","value":"1423-0208"}],"subject":[],"published":{"date-parts":[[2018]]}}}