{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:19:23Z","timestamp":1789593563372,"version":"build-2803163510"},"reference-count":13,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> The aim of this study is to assess the clinical effectiveness and safety of hyaluronic acid gel for the prevention of postoperative intrauterine adhesions (IUAs). <b><i>Methods:<\/i><\/b> PubMed, Cochrane Library, Embase and ClinicalTrials.gov databases were searched for randomized controlled trials. <b><i>Results:<\/i><\/b> Six RCTs with a total of 564 patients met the inclusion criteria. The meta-analysis showed that, compared to no other treatment method, hyaluronic acid gel significantly reduced the rate of any IUA (risk ratio [RR] 0.68; 95% CI 0.53\u20130.86; <i>p<\/i> = 0.03; <i>I<\/i><sup>2<\/sup> = 64%) and adhesion score (standard mean difference = \u20132.90; 95% CI \u20134.61 to \u20131.49; <i>p<\/i> &#x3c; 0.00001; <i>I<\/i><sup>2<\/sup> = 98%) following intraperitoneal or intrauterine surgery. Treatment lowered the rate of IUAs classified as moderate (RR 0.26; 95% CI 0.13\u20130.52; <i>p<\/i> = 0.13; <i>I<\/i><sup>2<\/sup> = 0%), but not those deemed mild (RR 0.86; 95% CI 0.62\u20131.21; <i>p<\/i> = 0.39; <i>I<\/i><sup>2<\/sup> = 3%) or severe (RR 0.33; 95% CI 0.03\u20133.09; <i>p<\/i> = 0.33; <i>I<\/i><sup>2<\/sup> = 0). Compliance with hyaluronic acid gel treatment was low. <b><i>Conclusion:<\/i><\/b> Hyaluronic acid gel can prevent IUAs, particularly those with moderate severity and a lower adhesion score.<\/jats:p>","DOI":"10.1159\/000486674","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T22:01:17Z","timestamp":1520460077000},"page":"227-233","source":"Crossref","is-referenced-by-count":34,"title":["Efficacy and Safety of Hyaluronic Acid Gel for the Prevention of Intrauterine Adhesion: A Meta-Analysis of Randomized Clinical Trials"],"prefix":"10.1159","volume":"83","author":[{"given":"Huafang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.096"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90382-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00571-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s10397-017-1007-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01954-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1281809"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg368"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh238"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.02.113"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei488"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00597-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001298.pub3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001298.pub4"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486674","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:36:18Z","timestamp":1745426178000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,5,4]]},"published-print":{"date-parts":[[2018,5,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000486674","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}