{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:11:22Z","timestamp":1777871482423,"version":"3.51.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; To assess the efficacy and tolerability of the new aerosol foam of calcipotriol 50 \u00b5g\/g plus betamethasone dipropionate 0.5 mg\/g (Cal\/BD foam, Enstilar\u00ae) in psoriasis vulgaris under daily practice conditions. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 410 adult psoriasis patients (56% male) from 87 German sites were enrolled in a 4-week, open-label, prospective, non-controlled, observational, non-interventional study. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; At baseline, patients presented with a psoriasis severity of mild (41.81%), moderate (49.63%), and severe (8.31%) assessed by an investigator global assessment (IGA). After 4 weeks of treatment, 49% of the patients achieved an IGA of clear\/almost clear. The mean affected body surface area was reduced from 12.91 to 7.55%, the PASI from 10.4 to 5.2 (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.0001). 43% of the patients with severe IGA achieved treatment success (IGA = 0\/1 and \u22652-step improvement). 93% of the patients did not show any adverse events. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The new Cal\/BD foam showed a convincing efficacy and tolerability profile in daily practice, particularly in patients with severer disease manifestations.<\/jats:p>","DOI":"10.1159\/000486700","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T22:07:29Z","timestamp":1520028449000},"page":"425-434","source":"Crossref","is-referenced-by-count":32,"title":["Prospective, Observational, Non-Interventional, Multicentre Study on the Efficacy and Tolerability of a New Calcipotriol\/Betamethasone Aerosol Foam (Enstilar\u00ae) in Patients with Plaque Psoriasis under Daily Practice Conditions"],"prefix":"10.1159","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6667-7757","authenticated-orcid":false,"given":"Sascha","family":"Gerdes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Krakor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Anger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u00a0Joachim","family":"Hutt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"K\u00f6rber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.039"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041320"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S81428"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13354"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1613-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2012.07919.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005028.pub3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12396"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0125-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1083935"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13859"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.865009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12118"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03831.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-62"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02211.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-011-2236-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0147-0"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:36:32Z","timestamp":1745426192000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,4,17]]},"published-print":{"date-parts":[[2018,4,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000486700","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5943238","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}