{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:39:27Z","timestamp":1763642367611,"version":"3.40.5"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Purpose:<\/i><\/b> The aim of this study was to examine the relationship between subclinical diabetic macular edema (SCME) and the development of central-involved macular edema (CIME) in patients with diabetes mellitus type-2 and mild nonproliferative diabetic retinopathy (NPDR), from 2 populations of different ethnicities. <b><i>Methods:<\/i><\/b> Two hundred and five patients with diabetes mellitus type-2 and mild NPDR with no prior laser or intravitreal treatment were followed for 2 years or until the development of CIME. Ophthalmological examinations, including BCVA, fundus photography with RetmarkerDR analysis, and optical coherence tomography were performed at baseline and months 6, 12, and 24. <b><i>Results:<\/i><\/b> One hundred and fifty eight eyes\/patients reached either the study endpoint, CIME (<i>n<\/i> = 24), or performed the 24-month visit without developing CIME (<i>n<\/i> = 134). Fifty eyes\/patients had SCME at baseline (31.6%). Of these 50 eyes, 16 (32.0%) developed CIME, whereas of the 108 eyes with normal retinal thickness (RT) at baseline, only 8 (7.4%) developed CIME (<i>p<\/i> &#x3c; 0.001). Patients with increased RT in the central subfield at baseline showed a 12-fold risk of progression to CIME compared with patients without SCME. <b><i>Conclusions:<\/i><\/b> In patients with mild NPDR, the presence of SCME is a good predictor of progression to CIME.<\/jats:p>","DOI":"10.1159\/000486792","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T22:01:22Z","timestamp":1520373682000},"page":"18-22","source":"Crossref","is-referenced-by-count":8,"title":["Subclinical Macular Edema as a Predictor of Progression to Central-Involved Macular Edema in Type 2 Diabetes"],"prefix":"10.1159","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5831-7711","authenticated-orcid":false,"given":"Concei\u00e7\u00e3o","family":"Lobo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Pires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalila","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev","family":"Pappuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00edsa","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Cunha-Vaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.3.330"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.08.038"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.53"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000484666"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10290"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000354550"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000403"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000213639"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11895"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318295f6de"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.2.211"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5301\/EJO.2010.6049"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19999"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001905"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:37:36Z","timestamp":1745426256000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,6,27]]},"published-print":{"date-parts":[[2018,7,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000486792","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2018]]}}}