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Karger AG","issue":"4-5","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Prompted by findings suggesting immune instability in infantile bilateral striatal necrosis (IBSN), we evaluated levels of proinflammatory (tumor necrosis factor \u03b1, interleukin [IL]-1\u03b2, IL-6, interferon [IFN]\u03b3) and anti-inflammatory (IL-10 and IL-1ra) cytokines produced by peripheral blood mononuclear cells (PBMC) from 6 children with IBSN and 11 age-matched controls. Compared to controls, non-stimulated PBMC from the IBSN group produced a significantly lower level of IL-1ra (by 38%; &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001) and significantly lower levels of TNF\u03b1, IL-1\u03b2, and IFN\u03b3 (by 36% [&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001], 25% [&lt;i&gt;p&lt;\/i&gt; = 0.06], and 32% [p &amp;#x3c; 0.02]) under PBMC stimulation. The severe cachexia manifesting shortly after IBSN onset may impair the immunological state, placing patients at risk of death from hyperpyrexia and sepsis.<\/jats:p>","DOI":"10.1159\/000486861","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T22:01:22Z","timestamp":1520373682000},"page":"276-281","source":"Crossref","is-referenced-by-count":0,"title":["Cytokine Production by Mononuclear Cells from Patients with Familial Infantile Bilateral Striatal Necrosis"],"prefix":"10.1159","volume":"24","author":[{"given":"Esther","family":"Ganelin\u00a0Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Bessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meir","family":"Djaldetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Straussberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520070035014"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380321"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7166"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10682"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-013-0355-z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36360"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.7.983"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20902"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162201002390"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(00)00105-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.12.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199612000-00015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05373.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R600021-JLR200"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/9780470513521.ch7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000091"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00218-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(07)96002-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1377"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(95)00018-C"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.06.011"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.446"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:38:24Z","timestamp":1745426304000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":22,"journal-issue":{"issue":"4-5","published-online":{"date-parts":[[2018,3,28]]},"published-print":{"date-parts":[[2018,4,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000486861","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"type":"print","value":"1021-7401"},{"type":"electronic","value":"1423-0216"}],"subject":[],"published":{"date-parts":[[2017]]}}}