{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:02Z","timestamp":1787017922526,"version":"build-2736575974"},"reference-count":25,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> The concentration assay of pleural effusion interleukin-27 (IL-27) has raised concern for diagnosing tuberculous pleurisy. Compared with malignant pleural effusion (MPE), the concentration of IL-27 in tuberculous pleural effusion (TPE) increased significantly. Accurate differentiating diagnosis is essential for choosing treatment for pleural effusion. <b><i>Objective:<\/i><\/b> The present meta-analysis is aimed at determining the accuracy of IL-27 in the differential diagnosis between TPE and MPE. <b><i>Material and<\/i><\/b> <b><i>Method:<\/i><\/b> After having retrieved the published studies, we combined the sensibility (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) of IL-27 in the diagnosis of TPE compared to MPE using a fixed-effect model. The summary receiver operating characteristic curve was applied to estimate the overall test performance. <b><i>Results:<\/i><\/b> In total, 550 patients (285 patients with TPE and 265 patients with MPE), included in 7 case-control studies, were enrolled. The summary assessments for IL-27 in the diagnosis between TPE and MPE were: SEN 0.93 (95% CI 0.90\u20130.96), SPE 0.97 (95% CI 0.94\u20130.98), PLR 25.88 (95% CI 13.84\u201348.39), NLR 0.07 (95% CI 0.05\u20130.11), and DOR 333.26 (95% CI 146.10\u2013760.19), respectively. The maximal joint SEN and SPE was 0.95; the area under the curve was 0.99. <b><i>Conclusion:<\/i><\/b> IL-27 determination is a relatively accurate test for the diagnosis of TPE, which has very high SEN and SPE for discriminating TPE from MPE. The results of IL-27 assays should be interpreted in parallel with clinical findings and the results of conventional tests.<\/jats:p>","DOI":"10.1159\/000486963","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T18:01:19Z","timestamp":1521050479000},"page":"469-477","source":"Crossref","is-referenced-by-count":35,"title":["Diagnostic Accuracy of Interleukin-27 between Tuberculous Pleural Effusion and Malignant Pleural Effusion: A Meta-Analysis"],"prefix":"10.1159","volume":"95","author":[{"given":"Qing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Xia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2012.11.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp010731"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00147507"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000468545"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00324-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0164-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2084"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0968-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1086\/589774"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040450"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-25"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.01.016"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136994"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2015.1098535"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.01941.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.150.6.1190"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.91.1.106"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.12.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2273"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00177-X"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510330081039"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000464253"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159\/000474952"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3109\/23744235.2015.1019919"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/srep19424"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:39:09Z","timestamp":1745411949000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,7,6]]},"published-print":{"date-parts":[[2018,7,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000486963","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}