{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:09:39Z","timestamp":1771909779629,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background and Aim:<\/i><\/b> Reddish depressed lesions (RDLs) frequently observed in patients following <i>Helicobacter pylori<\/i> eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant endoscopic diagnosis including magnifying narrow-band imaging (M-NBI). <b><i>Methods:<\/i><\/b> We enrolled 301 consecutive patients with <i>H. pylori<\/i> eradication who underwent endoscopy using white light imaging (WLI). We examined the prevalence and host factors contributing to the presence of RDLs. Next, we used M-NBI in 90 patients (104 RDLs), and compared the diagnostic efficacy between M-NBI and WLI groups using propensity-score matching analysis. <b><i>Results:<\/i><\/b> In 301 patients after eradication, 117 (39%) showed RDLs. Male, open-type atrophy, and gastric cancer history were risk factors for RDLs. A gastric biopsy was needed in 83 (71%) during WLI observation and only 2 were diagnosed with adenocarcinoma. In M-NBI group, a biopsy was performed in 21 (20%), and 9 were diagnosed with adenocarcinoma. A biopsy was required in fewer patients, and the positive predictive value of a biopsy was statistically higher in M-NBI than in the WLI group (<i>p<\/i> &#x3c; 0.01). <b><i>Conclusions:<\/i><\/b> RDLs are frequently observed in high-risk patients for gastric cancer after eradication. M-NBI demonstrated significantly superior diagnostic efficacy with respect to RDL.<\/jats:p>","DOI":"10.1159\/000487045","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T21:01:52Z","timestamp":1524171712000},"page":"48-55","source":"Crossref","is-referenced-by-count":15,"title":["Clinical Significance of Reddish Depressed Lesions Observed in the Gastric Mucosa after <b><i>Helicobacter pylori<\/i><\/b> Eradication"],"prefix":"10.1159","volume":"98","author":[{"given":"Takahiro","family":"Kotachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Boda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Kiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosaku","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Sanomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04776.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000460245"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00833.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000335260"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02360.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4021\/gr357w"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/den.12581"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000481346"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214594"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06527.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq224"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8230815"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0036-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.08.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000479553"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12132"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0479-y"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3887-2"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0764-7"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:39:30Z","timestamp":1745426370000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,6,19]]},"published-print":{"date-parts":[[2018,6,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000487045","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}