{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:02Z","timestamp":1787017922931,"version":"build-2736575974"},"reference-count":20,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Metastatic basal cell carcinoma is rare and the prognosis is poor, with a lack of established treatment options for patients progressing on or after treatment with inhibitors of the hedgehog signaling pathway. &lt;b&gt;&lt;i&gt;Case Report:&lt;\/i&gt;&lt;\/b&gt; A man with pulmonary metastases of a basal cell carcinoma progressing after treatment with sonidegib and vismodegib was started on treatment with the anti-PD-1 antibody pembrolizumab. Upon treatment, rapid clinical improvement occurred, and after 5 cycles, the computed tomography scan showed near-complete remission of all tumor lesions. The tumor cells showed the absence of PD-L1 expression. &lt;b&gt;&lt;i&gt;Discussion:&lt;\/i&gt;&lt;\/b&gt; We report the first case of a patient with metastatic basal cell carcinoma experiencing an exceptional response to treatment with pembrolizumab in the absence of PD-L1 expression on the tumor cells. Immune checkpoint inhibition seems a promising treatment strategy for metastatic basal cell carcinoma. Our case suggests that the lack of PD-L1 expression does not rule out potential benefit from checkpoint inhibitor treatment.<\/jats:p>","DOI":"10.1159\/000487084","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T17:01:34Z","timestamp":1525712494000},"page":"391-394","source":"Crossref","is-referenced-by-count":39,"title":["Anti-PD-1 Therapy Leads to Near-Complete Remission in a Patient with Metastatic Basal Cell Carcinoma"],"prefix":"10.1159","volume":"41","author":[{"given":"Stefanie","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar H.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Jochum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kluckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Flatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Siano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2015.06.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2546"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70198-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113713"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70100-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507643"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504627"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603702"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-3146"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-14-0983"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80008"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0386"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2834"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14664"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0228-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/npjgenmed.2016.37"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14642"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:39:53Z","timestamp":1745411993000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,5,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000487084","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"value":"2296-5270","type":"print"},{"value":"2296-5262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}