{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:54:51Z","timestamp":1772643291923,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Since the efficacy of ipilimumab on nivolumab-resistant advanced melanoma is extremely low, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma is needed. Although several supportive therapies that enhance the antitumor immune response of anti-PD-1 antibodies have already been reported, unexpected immune-related adverse events were detected at the same time. In this report, we describe a patient with advanced melanoma treated with nivolumab followed by intensity-modulated radiotherapy, which might have triggered bullous pemphigoid (BP). Although several cases of BP developing in anti-PD-1 antibody-treated patients have already been reported, in this report, we shed light on the possible pathogenesis of BP developing in a patient treated with nivolumab through M2 macrophages.<\/jats:p>","DOI":"10.1159\/000487127","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T22:01:26Z","timestamp":1518732086000},"page":"114-118","source":"Crossref","is-referenced-by-count":16,"title":["Intensity-Modulated Radiotherapy Triggers Onset of Bullous Pemphigoid in a Patient with Advanced Melanoma Treated with Nivolumab"],"prefix":"10.1159","volume":"11","author":[{"given":"Kayo","family":"Tanita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Kambayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tsukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yota","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504030"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3444-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13707"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17090"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14422"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13229"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000485612"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14085"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2017.1296764"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12091"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13157"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000365946"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01378.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/nature22396"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/srep15738"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.05.015"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12735"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14579"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0123"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:40:23Z","timestamp":1745426423000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,5,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000487127","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,15]]}}}