{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:58:16Z","timestamp":1770883096750,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; We investigated the prognosis of patients with myasthenia gravis (MG) initially presenting with only ocular symptoms in an Argentinian population. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; We performed a retrospective analysis of 61 patients with MG with pure ocular involvement at onset. Generalized MG (gMG) developed in 73.7% of patients, while the rest only exhibited ocular symptoms throughout the course of the disease (ocular MG [oMG]). The AChR antibody (AChR-ab) was found in 81.4% of the gMG and 50% of the oMG cases. AChR-ab titers were also significantly higher in the gMG than in the oMG group. Patients with oMG more frequently required treatment only with acetylcholinesterase inhibitors and showed more remissions. &lt;b&gt;&lt;i&gt;Key Messages:&lt;\/i&gt;&lt;\/b&gt; Our study showed high generalization in patients with MG debuting with ocular symptoms. Patients with AChR seropositivity and higher AChR-ab titers had an increased risk for gMG, while patients with oMG showed lower corticosteroid requirements and a higher remission rate.<\/jats:p>","DOI":"10.1159\/000487132","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T22:01:35Z","timestamp":1518213695000},"page":"113-117","source":"Crossref","is-referenced-by-count":23,"title":["Prognosis of Ocular Myasthenia Gravis in an Argentinian Population"],"prefix":"10.1159","volume":"79","author":[{"given":"Florencia","family":"Aguirre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres\u00a0M.","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140504"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00145-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.10.020"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb51317.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602678"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-013-0421-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20950"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.05.023"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.2.243"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.03.010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21555"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1444"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.166032"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00127893-200109000-00004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2009.5.2.53"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000065882.63904.53"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1988.tb06970.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5120-8"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200312000-00002"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:40:26Z","timestamp":1745426426000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":21,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2018,5,24]]},"published-print":{"date-parts":[[2018,5,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000487132","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}