{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:15:33Z","timestamp":1783026933606,"version":"3.54.6"},"reference-count":24,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disorder. Malignant transformation into malignant peripheral nerve sheath tumors (MPNST) can occur. However, urinary tract involvement is rare. We report 4 cases of NF1 with bladder dysfunction. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A retrospective single center analysis of 4 patients was conducted over a 17-year period, focusing on urinary tract involvement. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; NF1 was diagnosed at a median of 16.5 months (4\u201336) and urinary involvement occurred at a median of 5.25 years (4\u20139) after diagnosis. Bladder dysfunction was due to spinal cord compression in 2 cases, bladder invasion in 1 case, and cerebral lesions in 1 case. Malignant transformation of neurofibromas into MPNST occurred in 2 patients. Mechanisms of urinary involvement in NF1 are diverse and no pre-established protocol of management and follow-up exists. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Although rare, dysfunction of the bladder can arise in NF1 and innovative strategies then need to be considered. This is best achieved with the help of a multidisciplinary team and a national reference center when available.<\/jats:p>","DOI":"10.1159\/000487193","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T22:01:17Z","timestamp":1520460077000},"page":"339-345","source":"Crossref","is-referenced-by-count":11,"title":["Bladder Dysfunction in Children with Neurofibromatosis Type I: Report of Four Cases and Review of the Literature"],"prefix":"10.1159","volume":"100","author":[{"given":"Aurore","family":"Bouty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Dobremez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Harambat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Bouteiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Zaghet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Wolkenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Ducassou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lefevre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,3,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2006.01.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01083-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.3107130"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.02.019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197201000-00015"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604173141603"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000168830.79997.13"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.08.051"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00098-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900915)66:6<1253::AID-CNCR2820660627>3.0.CO;2-R"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.bpo.0000217719.10728.39"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00354-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.01.074"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13526"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(01)00452-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.163.3.8079855"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm450"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx124"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.19996"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.09.030"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/BF02307086"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.031"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2011.09.014"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(91)80242-Y"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:41:12Z","timestamp":1745426472000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,4,18]]},"published-print":{"date-parts":[[2018,4,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000487193","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}