{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:54:44Z","timestamp":1789901684923,"version":"4.0.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; There is no consensus regarding the optimal antenatal treatment of fetal\/neonatal alloimmune thrombocytopenia (F\/NAIT). We aimed to review the fetal blood sampling (FBS)-related risk, fetal response to maternal intravenous immunoglobulin (IVIG), and cesarean section (CS) rate in pregnancies with a history of F\/NAIT. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Maternal demographics, alloantibodies, pregnancy management, fetal and neonatal outcomes, and index case characteristics were collected. Responders (R) and non-responders (NR) were defined as women treated with IVIG in whom fetal platelets (PLTs) were normal or low (&amp;#x3c; 50 \u00d7 10&lt;sup&gt;9&lt;\/sup&gt;\/L). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; An FBS-related risk occurred in 1.6% (2\/119) of procedures. Maternal characteristics did not differ between responders (&lt;i&gt;n&lt;\/i&gt; = 21) and non-responders (&lt;i&gt;n&lt;\/i&gt; = 21). HPA-1a antibody was detected in all non-responders and in 72% of responders (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01). The index case had a significantly lower PLT count at birth in non-responders versus responders (median PLT count: R = 20 \u00d7 10&lt;sup&gt;9&lt;\/sup&gt;\/L [IQR 8\u201343] vs. NR = 9 \u00d7 10&lt;sup&gt;9&lt;\/sup&gt;\/L [IQR 4\u201318], &lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.02). No differences were found in IVIG treatment duration or dosage. PLTs at birth were significantly lower in non-responders compared to responders. No intracranial hemorrhages occurred. CSs were performed for obstetric indications only in all but two cases. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Maternal IVIG can elicit different fetal responses. The lack of prognostic factors to predict responders or non-responders suggests that there remains a role for FBS in F\/NAIT in experienced hands.<\/jats:p>","DOI":"10.1159\/000487303","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T21:02:52Z","timestamp":1524085372000},"page":"85-93","source":"Crossref","is-referenced-by-count":7,"title":["Management and Neonatal Outcomes of Pregnancies with Fetal\/Neonatal Alloimmune Thrombocytopenia: A Single-Center Retrospective Cohort Study"],"prefix":"10.1159","volume":"45","author":[{"given":"Stefania","family":"Ronzoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Keunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9920-0488","authenticated-orcid":false,"given":"Prakeshkumar\u00a0S.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond\u00a0N.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Windrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u00a0Gareth","family":"Seaward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91733-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707033370104"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3320"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12671"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004226.pub3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01367.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.025106"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-739656"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.04.033"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12235"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01244.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2017.1346471"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77820"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90559-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06418.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13550"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7696"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.116727"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122140"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04408.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000192404.25780.68"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111716"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:42:16Z","timestamp":1745426536000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,18]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,1,23]]},"published-print":{"date-parts":[[2019,1,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000487303","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,18]]}}}