{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:28:22Z","timestamp":1745468902681,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Objective:<\/i><\/b> To investigate the possible role of signal transducer and activator of transcription 5 (STAT5) in the pathogenesis of liver fibrosis in Egyptian patients with chronic hepatitis C (CHC) virus infection and its relation to hepatic stellate cells (HSC). <b><i>Subjects and<\/i><\/b> <b><i>Methods:<\/i><\/b> Sixty-five patients (46 males and 19 females) were divided into 4 groups based on the severity of fibrosis as detected by Fibroscan as follows: F1, <i>n<\/i> = 15; F2, <i>n<\/i> = 21; F3, <i>n<\/i> = 13; and F4,<i> n<\/i> = 16. Twenty age- and gender-matched healthy persons volunteered as controls. The serum levels of STAT5, TGF-\u03b2<sub>1<\/sub>, \u03b1-smooth muscle actin (\u03b1-SMA), fasting blood sugar, and fasting insulin, as well as homeostasis model assessment of insulin resistance (HOMA-IR), were determined and compared for all groups. The usefulness of the studied serum biomarkers for predicting liver fibrosis was evaluated using a receiver operating characteristic curve. <b><i>Results:<\/i><\/b> Serum levels of STAT5 were significantly lower in patients compared to controls (9.69 \u00b1 5.62 vs. 14.73 \u00b1 6.52, <i>p<\/i> \u2264 0.001); on the contrary, TGF-\u03b2<sub>1<\/sub>, \u03b1-SMA, and HOMA-IR were significantly higher in patients compared to controls (mean: 1,796.04 vs. 1,636.94; 14.94 vs. 8.1; and 7.91 vs. 4.18; <i>p<\/i> \u2264 0.01 and 0.001, respectively). TGF-\u03b2<sub>1<\/sub> and \u03b1-SMA showed a progressive increase with advancing severity of hepatic fibrosis (mean TGF-\u03b2<sub>1<\/sub>: 2,058.4 in F1-F2 and 1,583.8 in F3-F4, <i>p<\/i> \u2264 0.04; mean \u03b1-SMA: 13.59 in F1-F2 and 16.62 in F3-F4, <i>p<\/i> \u2264 0.05). STAT5 had a significant negative correlation with TGF-\u03b2<sub>1<\/sub> (<i>p<\/i> \u2264 0.001), while no correlation was detected with \u03b1-SMA (<i>p<\/i> \u2264 0.8). <b><i>Conclusions:<\/i><\/b> STAT5 may play a significant role in hepatic fibrogenesis through the induction of TGF-\u03b2<sub>1<\/sub> but not through the activation of hepatic stellate cells.<\/jats:p>","DOI":"10.1159\/000487308","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T22:01:26Z","timestamp":1517436086000},"page":"115-121","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Signal Transducer and Activator of Transcription 5 and Transforming Growth Factor-\u03b2<sub>1<\/sub> in Hepatic Fibrosis Induced by Chronic Hepatitis C Virus Infection in Egyptian Patients"],"prefix":"10.1159","volume":"27","author":[{"given":"Mona\u00a0A.","family":"Abu\u00a0El\u00a0Makarem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada\u00a0M.","family":"El-Sagheer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moustafa\u00a0A.","family":"Abu\u00a0El-Ella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,1,31]]},"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:42:18Z","timestamp":1745426538000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,5,2]]},"published-print":{"date-parts":[[2018,5,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000487308","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"type":"print","value":"1011-7571"},{"type":"electronic","value":"1423-0151"}],"subject":[],"published":{"date-parts":[[2018]]}}}