{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:27:21Z","timestamp":1790141241253,"version":"4.0.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Care"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Secondary lymphedema (SL) is a possible side effect of breast cancer treatment. Current data describe a positive influence of exercise on upper lymphedema. This systematic review evaluates studies examining a potential preventive effect of exercise on SL incidence. <b><i>Methods:<\/i><\/b> A systematic literature search of PubMed, LIVIVO, and the Cochrane Library was performed. <b><i>Results:<\/i><\/b> 8 randomized controlled trials were included in the review. 3 studies investigated the effect of strength training, and 5 the effect of combined exercise therapy. 5 studies included participants without lymphedema at study entry, and 3 studies included both patients with and without lymphedema. The partly significant results showed that progressive strength training as well as combined dynamic exercise therapies consisting of physiotherapy, physical therapy, and\/or kinesiotherapy are safe and can prevent SL. Onset as well as diagnosis of lymphedema were significantly decreased in 5 studies in the exercise group. <b><i>Conclusion:<\/i><\/b> All 8 studies included indicate a potential preventive effect of exercise on SL; however, further research is needed.<\/jats:p>","DOI":"10.1159\/000487428","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T21:01:23Z","timestamp":1525726883000},"page":"380-385","source":"Crossref","is-referenced-by-count":57,"title":["Does Exercise Have a Preventive Effect on Secondary Lymphedema in Breast Cancer Patients Following Local Treatment - A Systematic Review"],"prefix":"10.1159","volume":"13","author":[{"given":"Freerk T.","family":"Baumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Reike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Wiskemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Reimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.0735"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000001355"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e3181c5cd5a"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5396"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12B+<2798::AID-CNCR28>3.3.CO;2-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.08.018"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181e0c112"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-3068-z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810118"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1837"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/02841860903061683"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6749"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5326"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2015.0036"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2007.02187.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20050328"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.2.96"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.02.080"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0168"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22994"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2000.8117"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2010.000136"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009765.pub2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0736"}],"container-title":["Breast Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:43:22Z","timestamp":1745426602000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,10,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000487428","archive":["Portico"],"relation":{},"ISSN":["1661-3791","1661-3805"],"issn-type":[{"value":"1661-3791","type":"print"},{"value":"1661-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}