{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:37:46Z","timestamp":1783035466085,"version":"3.54.6"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Purpose:<\/i><\/b> To assess changes in visual field (VF) values after gene therapy for Leber\u2019s hereditary optic neuropathy (LHON). <b><i>Methods:<\/i><\/b> VF recovery, VF indices, and mean deviation in injected and uninjected eyes, before and after gene therapy, were examined in 2 groups of patients according to disease duration (\u22642 years and &#x3e; 2 years). Nine patients with LHON were treated by monocular intravitreal injection of AAV2-ND4. Finally, 7 patients were considered for subsequent comparisons; the first and second eyes were treated separately. <b><i>Results:<\/i><\/b> There were no significant differences in VF indices and mean deviation between injected and uninjected eyes (<i>p<\/i> = 0.910 and <i>p<\/i> = 0.929, respectively). However, there was a significant difference before and after injection (<i>p<\/i> = 0.016 and <i>p<\/i> = 0.015, respectively). There was no significant difference in VF improvement between patients with \u22642 years\u2019 disease duration and those with a longer disease duration. <b><i>Conclusion:<\/i><\/b> There was a statistically significant VF improvement after gene therapy. This suggests that monocular intravitreal injection of AAV2-ND4 can improve binocular VF values. This study also suggests that gene therapy can be effective in patients with a disease duration of &#x3e; 2 years.<\/jats:p>","DOI":"10.1159\/000487485","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:04:34Z","timestamp":1538773474000},"page":"176-184","source":"Crossref","is-referenced-by-count":15,"title":["Visual Field Variability after Gene Therapy for Leber\u2019s Hereditary Optic Neuropathy"],"prefix":"10.1159","volume":"60","author":[{"given":"Jia-jia","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-shi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-qi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02815.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.09.110"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005110"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/srep21587"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.07.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12547"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.11.002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr170"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01825-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802315"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802268"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.12.045"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.37"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.7971"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:43:40Z","timestamp":1745426620000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,10,3]]},"published-print":{"date-parts":[[2018,10,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000487485","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}