{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:06:11Z","timestamp":1777039571851,"version":"3.51.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Purpose:<\/i><\/b> To present functional and anatomic outcomes of combination therapy with ranibizumab and photodynamic therapy (PDT) in a series of retinal angiomatous proliferation (RAP) cases. <b><i>Methods:<\/i><\/b> A total of 17 eyes of 17 patients with RAP were included. Thirteen eyes were treatment na\u00efve and 4 were already on ranibizumab monotherapy. Combined treatment with single-dose ranibizumab and PDT was performed on all treatment-na\u00efve cases. Follow-up was performed every month for 6\u201338 months, using optical coherence tomography and indocyanine green angiography when necessary. <b><i>Results:<\/i><\/b> Overall, 6 out of 7 treatment-na\u00efve cases with stage I or II disease manifested complete angiographic resolution of the hot spot with a single injection of ranibizumab plus PDT. In stage III disease, 7 out of 10 eyes showed persistent leakage immediately after the combined treatment. The rate of hot spot occlusion was found to correlate with the stage of disease (<i>p<\/i> = 0.05). There was a significant improvement in posttreatment BCVA for all patients regardless of disease stage (<i>p<\/i> = 0.02), which was more evident in the earlier stages. Improvement was also greater for treatment-na\u00efve patients (<i>p<\/i> = 0.03). The posttreatment improvement in BCVA was strongly correlated with hot spot occlusion (<i>p<\/i> &#x3c; 0.001). <b><i>Conclusions:<\/i><\/b> Single-dose modified anti-VEGF treatment in combination with PDT may provide long-term regression at the initial stages of RAP.<\/jats:p>","DOI":"10.1159\/000487610","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T22:31:35Z","timestamp":1526509895000},"page":"213-221","source":"Crossref","is-referenced-by-count":5,"title":["Long-Term Results of Combination Treatment with Single-Dose Ranibizumab plus Photodynamic Therapy for Retinal Angiomatous Proliferation"],"prefix":"10.1159","volume":"240","author":[{"given":"Panagiotis","family":"Malamos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Tservakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menelaos","family":"Kanakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrysoula","family":"Koutsiouki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evita","family":"Kiskira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Mylonas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lakoumentas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Georgalas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200110000-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00166756"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30389-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181a395cb"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00009-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.06.072"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182979e62"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304251"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318235d8ce"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.08.038"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2013.27.5.351"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17279"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.11.1460"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.08.012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054481"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.011"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.042"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.12.1644"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-012-0215-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.06.033"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12111"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181a0be1d"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.01952.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181e586e3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181af106d"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318030ea80"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001104"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318162d982"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0580-y"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181669504"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:45:05Z","timestamp":1745426705000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,11,29]]},"published-print":{"date-parts":[[2018,12,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000487610","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}