{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:50:38Z","timestamp":1788306638759,"version":"build-2803163510"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Careful control of glucose homeostasis is essential for infants with very low birth weight (VLBW). In clinical practice, blood and urine glucose levels are monitored; however, their correlation has not been fully investigated in VLBW infants. <b><i>Objectives:<\/i><\/b> To evaluate the correlation between interstitial fluid glucose concentration (ISFG), glycosuria, and urine output among VLBW infants through continuous glucose monitoring (CGM). <b><i>Methods:<\/i><\/b> A prospective, single-center, open cohort study enrolled 74 VLBW infants with a mean birth weight of 1,066 g. CGM (Guardian Real-Time CGM\u00ae; Medtronic, Northridge, CA, USA) was used to measure glucose. The urine output was calculated using 4-hour intervals. Reagent strips were used for semiquantitative measurement of glycosuria. <b><i>Results:<\/i><\/b> The CGM delivered 102,334 glucose measurements. 2,684 urine samples were checked for glycosuria, of which 92.06% remained negative. Corresponding glycemia in samples without glycosuria remained normoglycemic (median 103 mg\/dL; 10\u201390th percentile 80\u2013144 mg\/dL). The median glucose concentrations for samples in ascending glycosuria categories 1+, 2+, 3+, and 4+ were 152, 181, 214, and 222 mg\/dL, respectively. A moderate correlation between ISFG and urine output was found for categories \u22651+ (<i>r<\/i><sub><i>s<\/i><\/sub> = 0.56; 95% confidence interval 0.42\u20130.68; <i>p<\/i> &#x3c; 0.001). The urine output was significantly lower when glycosuria was absent (<i>p<\/i> &#x3c; 0.05). Polyuria was observed only in glycosuria 4+ (median urine output 9.9; interquartile range 7.4\u201312.2 mL\/kg\/h). <b><i>Conclusions:<\/i><\/b> The renal glucose threshold in VLBW infants is between 150 and 180 mg\/dL. A negative result for glycosuria is a reliable screening test to exclude hyperglycemia. Occurrence of glycosuria \u22651+ is an indication to test blood glucose.<\/jats:p>","DOI":"10.1159\/000487846","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T21:01:19Z","timestamp":1525294879000},"page":"87-92","source":"Crossref","is-referenced-by-count":14,"title":["Preterm Glycosuria \u2013 New Data from a Continuous Glucose Monitoring System"],"prefix":"10.1159","volume":"114","author":[{"given":"Mateusz","family":"Jag\u0142a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Szymo\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Starzec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3017-0348","authenticated-orcid":false,"given":"Przemko","family":"Kwinta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2013.12.008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.10_Spec_No.1162"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.051979"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211593"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.04.068"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2005.04.008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.04.032"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000165980"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0425-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(62)80003-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-301661"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:46:53Z","timestamp":1745426813000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,6,12]]},"published-print":{"date-parts":[[2018,6,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000487846","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.6210059","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}