{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:36:22Z","timestamp":1792150582195,"version":"4.4.0"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Withholding enteral feedings during hypothermia lacks supporting evidence. <b><i>Objectives:<\/i><\/b> We aimed to determine if minimal enteral nutrition (MEN) during hypothermia in patients with hypoxic-ischemic encephalopathy was associated with a reduced duration of parenteral nutrition, time to full oral feeds, and length of stay, but would not be associated with increased systemic inflammation or feeding complications. <b><i>Methods:<\/i><\/b> We performed a pilot, retrospective, matched case-control study within the Florida Neonatal Neurologic Network from December 2012 to May 2016 of patients who received MEN during hypothermia (<i>n<\/i> = 17) versus those who were not fed (<i>n<\/i> = 17). Length of stay, feeding-related outcomes, and brain injury identified by MRI were compared. Serum inflammatory mediators were measured at 0\u20136, 24, and 96 h of life by multiplex assay. MRI were scored using the Barkovich system. <b><i>Results:<\/i><\/b> MEN subjects had a reduced length of hospital stay (mean 15 \u00b1 11 vs. 24 \u00b1 19 days, <i>p<\/i> &#x3c; 0.05), days receiving parenteral nutrition (7 \u00b1 2 vs. 11 \u00b1 6, <i>p<\/i> &#x3c; 0.05), and time to full oral feeds (8 \u00b1 5 vs. 18 \u00b1 18, <i>p<\/i> &#x3c; 0.05). MEN was associated with a significantly reduced serum IL-12p70 at 24 and 96 h (<i>p<\/i>\u2009&#x3c;\u20090.05). Brain MRI scores were not significantly different between groups. <b><i>Conclusion:<\/i><\/b> MEN during hypothermia was associated with a reduced length of stay and time to full feeds, but did not increase feeding complications or systemic inflammation.<\/jats:p>","DOI":"10.1159\/000487848","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T22:01:28Z","timestamp":1520373688000},"page":"347-352","source":"Crossref","is-referenced-by-count":47,"title":["Enteral Feeding as an Adjunct to Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1159","volume":"113","author":[{"given":"Lilly\u00a0L.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u00a0L.","family":"Wynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa\u00a0J.","family":"Pacella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace\u00a0C.","family":"Rossignol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Banadera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Alviedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Huene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Copenhaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Sura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Barnette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay\u00a0A.","family":"Bliznyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Neu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u00a0D.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9293"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.1772"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811209023086"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.01.001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3269"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2174\/1874143620130805001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041996"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2174\/157489111796887837"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0b013e31805569df"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.146"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19980058"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132924"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12838"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058838"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318271bb61"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.06.015"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.83"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.280"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2366"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:46:54Z","timestamp":1745426814000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,5,31]]},"published-print":{"date-parts":[[2018,5,29]]}},"URL":"https:\/\/doi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