{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:37:12Z","timestamp":1761863832185,"version":"3.40.5"},"reference-count":29,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Allergen provocation tests are useful methods for proving the clinical relevance of an allergen-specific sensitization. Among these methods, the conjunctival provocation test (CPT) represents an easy-to-use tool. However, its readout parameters have not yet been internationally standardized or validated. Photodocumentation has been shown as a good option for objectifying a CPT reaction, supporting the local investigator assessment. Based on test-retest reliability of the score and an objective digital photoanalysis of the conjunctival redness, this study aimed to prove the reproducibility of a new CPT scoring system for use in clinical trials (ClinicalTrials.gov identifier: NCT02690740). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A titrated quantitative CPT was conducted outside of the pollen season in a final cohort of 23 adult patients with birch or grass pollen-induced allergic rhinoconjunctivitis. Conjunctival symptoms were analyzed using a standardized symptom score. Conjunctival redness was also evaluated by an external observer and correlated with a digital photoanalysis using MATLAB software. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A test-retest correlation of 0.6 (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01) was found for the symptom score results. Likewise, a correlation of 0.65 (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01) was observed in the digital photoanalysis. The total symptom score showed a decrease in the mean value of 0.48 score points in the retest. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; This study reveals both a valuable test-retest correlation of the proposed score as well as a good correlation of eye redness with the (objective) photodocumentation. Based on our results, we can recommend the use of this scoring system as a valuable clinical protocol for future clinical trials.<\/jats:p>","DOI":"10.1159\/000487884","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T22:31:35Z","timestamp":1526509895000},"page":"215-224","source":"Crossref","is-referenced-by-count":8,"title":["Reliability of a New Symptom Score in a Titrated Quantitative Conjunctival Provocation Test Supported by an Objective Photodocumentation"],"prefix":"10.1159","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-9639","authenticated-orcid":false,"given":"Oliver","family":"Pfaar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan\u00a0Philipp","family":"Cla\u00dfen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatoli","family":"Astvatsatourov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludger","family":"Klimek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"M\u00f6sges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-012-1652-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61895-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/all.12383"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2003.08.007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/all.13416"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(59)90003-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(49)90085-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000068369"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1993.93"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1986.tb00319.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.12932\/AP0237.31.3.2013"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1984.tb01931.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)80022-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070030090035"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/all.12986"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.157"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02594.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90036-F"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200210000-00008"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1994.tb00808.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3508"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410702"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07055-4"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000355333"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3414\/ME13-12-0142"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000443273"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/BF00383590"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:47:09Z","timestamp":1745426829000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":29,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2018,7,11]]},"published-print":{"date-parts":[[2018,7,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000487884","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2018]]}}}