{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:32:12Z","timestamp":1778070732283,"version":"3.51.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> We aimed to clarify associations between pre-admission risk scores (CHADS<sub>2<\/sub>, CHA<sub>2<\/sub>DS<sub>2<\/sub>-VASc, and HAS-BLED) and 2-year clinical outcomes in ischemic stroke or transient ischemic attack (TIA) patients with non-valvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry. <b><i>Methods:<\/i><\/b> From 18 Japanese stroke centers, ischemic stroke or TIA patients with NVAF hospitalized within 7 days after onset were enrolled. Outcome measures were defined as death\/disability (modified Rankin Scale score \u22653) at 2 years, 2-year mortality, and ischemic or hemorrhagic events within 2 years. <b><i>Results:<\/i><\/b> A total of 1,192 patients with NVAF (527 women; mean age, 78 \u00b1 10 years), including 1,141 ischemic stroke and 51 TIA, were analyzed. Rates of death\/disability, mortality, and ischemic or hemorrhagic events increased significantly with increasing pre-admission CHADS<sub>2<\/sub> (<i>p<\/i> for trend &#x3c;0.001 for death\/disability and mortality, <i>p<\/i> for trend = 0.024 for events), CHA<sub>2<\/sub>DS<sub>2<\/sub>-VASc (<i>p<\/i> for trend\u00a0&#x3c;0.001 for all), and HAS-BLED (<i>p<\/i> for trend = 0.004 for death\/disability, <i>p<\/i> for trend &#x3c;0.001 for mortality, <i>p<\/i> for trend\u00a0= 0.024 for events) scores. Pre-admission CHADS<sub>2<\/sub> (OR per 1 point, 1.52; 95% CI 1.35\u20131.71; <i>p<\/i> &#x3c;0.001 for death\/disability; hazard ratio (HR) per 1 point, 1.23; 95% CI 1.12\u20131.35; <i>p<\/i> &#x3c;0.001 for mortality; HR per 1 point, 1.14; 95% CI 1.02\u20131.26; <i>p<\/i> = 0.016 for events), CHA<sub>2<\/sub>DS<sub>2<\/sub>-VASc (1.55, 1.41\u20131.72, <i>p<\/i> &#x3c; 0.001; 1.21, 1.12\u20131.30, <i>p<\/i> &#x3c; 0.001; 1.17, 1.07\u20131.27, <i>p<\/i> &#x3c; 0.001; respectively), and HAS-BLED (1.33, 1.17\u20131.52, <i>p<\/i> &#x3c; 0.001; 1.23, 1.10\u20131.38, <i>p\u00a0<\/i>&#x3c; 0.001; 1.18, 1.05\u20131.34, <i>p<\/i> = 0.008; respectively) scores were independently associated with all outcome measures. <b><i>Conclusions:<\/i><\/b> In ischemic stroke or TIA patients with NVAF, all pre-admission risk scores were independently associated with death\/disability at 2 years and 2-year mortality, as well as ischemic or hemorrhagic events within 2 years.<\/jats:p>","DOI":"10.1159\/000487896","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T21:01:34Z","timestamp":1522357294000},"page":"170-179","source":"Crossref","is-referenced-by-count":4,"title":["Associations between Pre-Admission Risk Scores and Two-Year Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients with Non-Valvular Atrial Fibrillation"],"prefix":"10.1159","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0701-3635","authenticated-orcid":false,"given":"Keisuke","family":"Tokunaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6758-4026","authenticated-orcid":false,"given":"Masatoshi","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Todo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Itabashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Terasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-0905","authenticated-orcid":false,"given":"Yoshiaki","family":"Shiokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kamiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4567-6384","authenticated-orcid":false,"given":"Shunya","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Kameda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-7077","authenticated-orcid":false,"given":"Yoshinari","family":"Nagakane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3200-376X","authenticated-orcid":false,"given":"Yasuhiro","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Yagita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanari","family":"Kitazono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Takasugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Okata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohei","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3966-6048","authenticated-orcid":false,"given":"Shoji","family":"Arihiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"SAMURAI 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