{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:33:02Z","timestamp":1761766382169,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Minimally invasive surfactant therapy (MIST) is increasingly used to treat preterm infants with respiratory distress syndrome (RDS). However, the effect of MIST on breathing effort is poorly studied. <b><i>Objectives:<\/i><\/b> To describe the effect of MIST on neural breathing effort assessed with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants with RDS. <b><i>Methods:<\/i><\/b> Preterm infants with a gestational age &#x3c; 37 weeks treated with MIST for RDS were included. dEMG measurements were done from 15 min before to 1 h after MIST. The percentage change in dEMG activity after MIST and the clinical response were analyzed. <b><i>Results:<\/i><\/b> Twenty preterm infants (mean gestational age 29.3 [SD 2.1] weeks; mean birth weight 1,230 [SD 391] g) were included. Seventeen infants did complete the 1-h measurement. Eleven (65%) infants had a decrease in their peak<sub>dEMG<\/sub> activity (median change \u201311.8% [IQR \u201326.8 to 5.8, <i>p<\/i> = 0.08]) 1 h after MIST. Tonic<sub>dEMG<\/sub> activity decreased in 12 (71%) infants, with a median reduction of 6.3% (IQR \u201329.2 to 9.0, <i>p<\/i> = 0.07). FiO<sub>2<\/sub> showed a rapid decrease following MIST (before, 0.47 [IQR 0.38\u20130.84]; 1 h after, 0.25 [IQR 0.21\u20130.30], <i>p<\/i> &#x3c; 0.001). <b><i>Conclusion:<\/i><\/b> In addition to improved oxygenation, MIST results in a decrease in neural breathing effort measured by dEMG activity in the majority of preterm infants with RDS.<\/jats:p>","DOI":"10.1159\/000487916","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T21:01:19Z","timestamp":1525294879000},"page":"76-81","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Minimally Invasive Surfactant Therapy on Diaphragmatic Activity"],"prefix":"10.1159","volume":"114","author":[{"given":"Cornelia\u00a0G.","family":"de\u00a0Waal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard\u00a0J.","family":"Hutten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans\u00a0H.","family":"de\u00a0Jongh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton\u00a0H.","family":"van\u00a0Kaam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0128PS"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2008.12.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211320"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60986-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-213"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0603"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.11.035"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23116"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.4.1410"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.6.1955"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199211000-00023"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201103-0375OC"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211160"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81228-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-0989-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.04.040"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311440"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950150306"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.4.830"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.3.1117"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199426030-00005"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81660-9"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487916","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:47:47Z","timestamp":1745426867000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,6,12]]},"published-print":{"date-parts":[[2018,6,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000487916","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2018]]}}}