{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:50:02Z","timestamp":1780595402373,"version":"3.54.1"},"reference-count":34,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> High-quality chest compression is essential during neonatal cardiopulmonary resuscitation (CPR). However, the optimal compression to ventilation ratio (C:V) that should be used during neonatal CPR to optimize coronary and cerebral perfusion while providing adequate ventilation remains unknown. <b><i>Objective:<\/i><\/b> We hypothesized that different C:V ratios (e.g., 2: 1 or 4: 1) will reduce the time to return of spontaneous circulation (ROSC) in severely asphyxiated piglets. <b><i>Methods:<\/i><\/b> Thirty-one newborn piglets (1\u20134 days old) were anesthetized, intubated, instrumented, and exposed to 50-min normocapnic hypoxia followed by asphyxia. Piglets were randomized into 4 groups: 2: 1 (<i>n<\/i> = 8), 3: 1 (<i>n<\/i> = 8), 4: 1 (<i>n<\/i> = 8) C:V ratio, or a sham group (<i>n<\/i> = 7). Cardiac function, carotid blood flow, cerebral oxygenation, and respiratory parameters were continuously recorded throughout the experiment. <b><i>Results:<\/i><\/b> Thirty-one piglets were included in the study, and there was no difference in the duration of asphyxia or the degree of asphyxiation (as indicated by pH, PaCO<sub>2<\/sub>, and lactate) among the different groups. The median (IQR) time to ROSC was similar between the groups with 127 (82\u2013210), 96 (88\u2013126), and 119 (83\u2013256) s in the 2: 1, 3: 1, and 4: 1 C:V ratio groups, respectively (<i>p<\/i> = 0.67 between groups). Similarly, there was no difference in 100% oxygen requirement or epinephrine administration between the experimental groups. <b><i>Conclusions:<\/i><\/b> Different C:V ratios resulted in similar ROSC, mortality, oxygen, and epinephrine administration during resuscitation in a porcine model of neonatal asphyxia.<\/jats:p>","DOI":"10.1159\/000487988","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T21:01:40Z","timestamp":1523566900000},"page":"37-45","source":"Crossref","is-referenced-by-count":38,"title":["Comparison of Different Compression to Ventilation Ratios (2: 1, 3: 1, and 4: 1) during Cardiopulmonary Resuscitation in a Porcine Model of Neonatal Asphyxia"],"prefix":"10.1159","volume":"114","author":[{"given":"Matteo\u00a0P.","family":"Pasquin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-1523","authenticated-orcid":false,"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sparsh","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze-Fun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-2310","authenticated-orcid":false,"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"O\u2019Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg\u00a0M.","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.3.618"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.70"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.71"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.222"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000276"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000267"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.07.045"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2012.09.011"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13339"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.06.007"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-20-73"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.200386"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1983.11.2.103"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000477998"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.165878"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12650"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.07.007"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-309761"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.08.001"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2013.10.011"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002289"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157249"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-313037"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001248"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00003"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301334"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000161621.74554.15"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308363"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2174\/1874306401206010089"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.167"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.174003"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.191171"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182125f7f"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487988","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/487988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:48:19Z","timestamp":1745426899000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000487988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,6,12]]},"published-print":{"date-parts":[[2018,6,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000487988","archive":["Portico"],"relatio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