{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:11:32Z","timestamp":1792098692328,"version":"4.4.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Arterial stiffness (AS) and vascular calcification are significantly related to a high cardiovascular mortality risk in hemodialysis (HD) patients. Intravenous sodium thiosulfate (IV STS) can prevent and delay the vascular calcification progression in uremic states; however, the STS effect on AS has not been assessed. This study aimed to evaluate the STS efficacy on vascular calcification and AS in HD patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Fifty HD patients with abnormal AS, as measured via the cardio-ankle vascular index (CAVI \u22658), were prospectively randomized to open-label 12.5 g IV STS during the last HD hour twice weekly for 6 months (&lt;i&gt;n&lt;\/i&gt; = 24) or the usual care (control group; &lt;i&gt;n&lt;\/i&gt; = 26). Patients and treating physicians were not blinded. The CAVI, coronary artery calcification (CAC) score, hemodynamics, and biochemical parameters were measured at the baseline and at 3 and 6 months. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; All the baseline parameters were comparable. The IV STS significantly reduced the CAVI when compared to the control group (mean CAVI difference = \u20130.53; 95% CI \u20131.00 to \u20130.06; &lt;i&gt;p&lt;\/i&gt; = 0.03). A significant CAVI improvement was seen in those patients without diabetes mellitus. The natural logarithm of the CAC volume score was significantly increased in the control group. The high sensitivity C-reactive protein level was slightly lowered in the IV STS group (not significant). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The intradialytic STS treatment significantly reduced the AS, as measured by the CAVI, and stabilized the vascular calcification in the HD patients. STS may be a novel therapeutic strategy for delaying and treating the structural and functional vascular wall abnormalities in HD patients.<\/jats:p>","DOI":"10.1159\/000488009","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T22:01:14Z","timestamp":1521842474000},"page":"219-227","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Sodium Thiosulfate on Arterial Stiffness in End-Stage Renal Disease Patients Undergoing Chronic Hemodialysis (Sodium Thiosulfate-Hemodialysis Study): A Randomized Controlled Trial"],"prefix":"10.1159","volume":"139","author":[{"given":"Donlawat","family":"Saengpanit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pairoj","family":"Chattranukulchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monravee","family":"Tumkosit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monchai","family":"Siribumrungwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisut","family":"Katavetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visith","family":"Sitprija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kearkiat","family":"Praditpornsilpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Eiam-Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paweena","family":"Susantitaphong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.12.004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.7.987"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.06.016"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000201416"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.09.037"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000245067"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12055"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2012.01058.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.5551\/jat.E584"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2009.00528.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl254"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834fa8b0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.06.007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.335"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.99"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.455"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp755"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000323550"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124881"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-4-4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-004-8786-y"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5551\/jat.7716"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.208.3.9722864"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.038"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S65275"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.08.018"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.131"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh015"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm828"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2011.2566"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.02.040"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:48:27Z","timestamp":1745426907000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,6,26]]},"published-print":{"date-parts":[[2018,7,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000488009","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.6021599","asserted-by":"subject"}]},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"publis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