{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:29:05Z","timestamp":1747193345507,"version":"3.40.5"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>An 87-year-old woman not known to have either a lymphoma or leukemia developed a left multinodular, fish-flesh superior epibulbar and forniceal mass. A biopsy disclosed a blastic tumor with scattered multinucleated immature megakaryoblasts. Immunophenotyping of bone marrow cells revealed strong positivity for CD7, CD31, CD43, CD45, CD61, and CD117; CD71, myeloperoxidase, and lysozyme were also positive in scattered cells. Forty percent of the neoplastic cells were Ki-67 positive. Cytogenetic studies indicated a trisomy 8 (associated with worse prognosis) and a t(12; 17) translocation. Desmin, smooth muscle actin, pancytokeratin, CAM 5.2, adipophilin, tryptase, S100, SOX10, MART1, and E-cadherin were negative, ruling out a nonhematopoietic tumor. The conjunctival lesion was diagnosed as a myeloid sarcoma with megakaryoblastic differentiation, a rare variant. It probably arose from a myelodysplastic syndrome. This is the first case of its type to develop in the conjunctiva.<\/jats:p>","DOI":"10.1159\/000488057","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T21:01:22Z","timestamp":1527022882000},"page":"28-35","source":"Crossref","is-referenced-by-count":3,"title":["Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva"],"prefix":"10.1159","volume":"5","author":[{"given":"Frederick\u00a0A.","family":"Jakobiec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-115X","authenticated-orcid":false,"given":"Natalie","family":"Wolkow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fouad\u00a0R.","family":"Zakka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter\u00a0A.D.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq097"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701308"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2013.06.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14430"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12071"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1924-1"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0341-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e318073cf70"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.09.007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.127"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-2-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19911115)68:10<2266::AID-CNCR2820681027>3.0.CO;2-B"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25103"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404699"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199809)31:3<144::AID-MPO3>3.0.CO;2-B"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.447"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.69"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403804"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23703"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.22071"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2015.03.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1177\/2040620711410774"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:48:45Z","timestamp":1745426925000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,22]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,4]]},"published-print":{"date-parts":[[2019,1,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000488057","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"type":"print","value":"2296-4681"},{"type":"electronic","value":"2296-4657"}],"subject":[],"published":{"date-parts":[[2018,5,22]]}}}