{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:30:10Z","timestamp":1761514210165,"version":"3.40.5"},"reference-count":16,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Extracorporeal photopheresis (ECP) is a second-line therapy for steroid-refractory chronic graft-versus-host disease (cGVHD). &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We describe the long-term efficacy and tolerability of ECP according to the cutaneous phenotype of cGVHD and report on the reduced need for immunosuppressant drugs in this setting. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; Fourteen patients (8 females) with cutaneous and\/or mucosal cGVHD, treated with ECP between October 2010 and May 2016 within a single center, were included. Final analyses included patients who had received ECP for at least 12 months. We prospectively evaluated the efficacy of ECP using lesion-specific clinical scores and by recording changed doses of systemic immunosuppressants. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of the 14 patients, sclerotic skin lesions were present in 10 (71%). The mRODNAN score decreased in all patients from month 9 onwards, with 40 and 77% reductions at 12 and 36 months, respectively. Six patients (43%) presented with cutaneous lichenoid lesions: this score was reduced in all patients by month 3, reaching a 93% reduction by month 12. Five patients (36%) experienced oral mucosal lichenoid lesions: these scores were decreased by 55% at month 12 and by 100% by month 33. The use of systemic immunosuppressants was reduced in all patients; 4 patients could stop all immunosuppressant drugs after 2 years. ECP was stopped in 3 patients after a complete response. No major ECP-associated adverse effects were observed. &lt;b&gt;&lt;i&gt;Discussion and Conclusion:&lt;\/i&gt;&lt;\/b&gt; ECP was an effective long-term therapy for oral and cutaneous cGVHD: consequently, dose levels of therapeutic immunosuppression could be reduced.<\/jats:p>","DOI":"10.1159\/000488238","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T21:01:22Z","timestamp":1527022882000},"page":"23-30","source":"Crossref","is-referenced-by-count":6,"title":["Extracorporeal Photopheresis: An Efficacious and Well-Tolerated Treatment for Cutaneous and Oral Mucosal Chronic Graft-versus-Host Disease"],"prefix":"10.1159","volume":"234","author":[{"given":"Camille","family":"Richet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00e9","family":"Dimeglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Borel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beno\u00eet","family":"Lepage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Boulinguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u00a0Claude","family":"Marguery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carle","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-6868","authenticated-orcid":false,"given":"Cristina","family":"Bulai\u00a0Livideanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.6.1687"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5426.412"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705440"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-208983"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.09.004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12311"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20524"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.186"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.02.033"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.05.017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.21"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.12.3192"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-204750"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.21"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14537"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:50:47Z","timestamp":1745427047000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":16,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2018,7,19]]},"published-print":{"date-parts":[[2018,7,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000488238","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.6303926","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2018]]}}}