{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:21:03Z","timestamp":1761920463122,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Methionine sulfoxide reductases (&lt;i&gt;MsrA&lt;\/i&gt; and &lt;i&gt;MsrB&lt;\/i&gt;) protect the biological activity of proteins from oxidative modifications to methionine residues and are important for protecting against the pathological effects of neurodegenerative diseases. In the current study, we characterized the auditory phenotype of the &lt;i&gt;MsrA&lt;\/i&gt; knockout mouse. Young &lt;i&gt;MsrA&lt;\/i&gt; knockout mice showed small high-frequency threshold elevations for auditory brainstem response and distortion product otoacoustic emission compared to those of wild-type mice, which progressively worsened in older &lt;i&gt;MsrA&lt;\/i&gt; knockout mice. &lt;i&gt;MsrA&lt;\/i&gt; knockout mice showed an increased sensitivity to noise at young and older ages, suggesting that &lt;i&gt;MsrA&lt;\/i&gt; is part of a mechanism that protects the cochlea from acoustic damage. &lt;i&gt;MsrA&lt;\/i&gt; mRNA in the cochlea was increased following acoustic stimulation. Finally, expression of mRNA &lt;i&gt;MsrB1&lt;\/i&gt; was compromised at 6 months old, but not in younger &lt;i&gt;MsrA&lt;\/i&gt; knockout mice (compared to controls). The identification of &lt;i&gt;MsrA&lt;\/i&gt; in the cochlea as a protective mediator from both early onset hearing loss and acoustic trauma expands our understanding of the pathways that&lt;b&gt;&lt;i&gt;&lt;\/i&gt;&lt;\/b&gt; may induce protection from acoustic trauma and foster further studies on how to prevent the damaging effect of noise exposure through Msr-based therapy.<\/jats:p>","DOI":"10.1159\/000488276","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T21:01:40Z","timestamp":1529614900000},"page":"20-31","source":"Crossref","is-referenced-by-count":11,"title":["Methionine Sulfoxide Reductase A Knockout Mice Show Progressive Hearing Loss and Sensitivity to Acoustic Trauma"],"prefix":"10.1159","volume":"23","author":[{"given":"Safa","family":"Alqudah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Chertoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Durham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackob","family":"Moskovitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hinrich","family":"Staecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Peppi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,6,21]]},"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:51:17Z","timestamp":1745427077000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,8,29]]},"published-print":{"date-parts":[[2018,9,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000488276","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"type":"print","value":"1420-3030"},{"type":"electronic","value":"1421-9700"}],"subject":[],"published":{"date-parts":[[2018]]}}}