{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:02Z","timestamp":1787017922478,"version":"build-2736575974"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Little has been reported on long-term pulmonary function trends among patients with interstitial lung disease associated with anti-aminoacyl-tRNA synthetase antibodies (ARS-ILD). &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To clarify the factors predictive of progression in ARS-ILD based on patients\u2019 initial clinical and radiological features. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The clinical courses of 88 patients with &amp;#x3e; 1 year of follow-up data on pulmonary function tests (PFTs) were retrospectively analyzed. Disease behavior was categorized into three groups: (1) improved or (2) worsened (defined as increases or decreases, respectively, of &amp;#x3e; 10% in forced vital capacity and &amp;#x3e; 15% in %diffusing capacity of lung carbon monoxide) or (3) stable based on PFT changes compared between 1-year results as the initial data and results at 3 years to assess the long-term course. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In the initial course of 75 patients with ARS-ILD who received anti-inflammatory therapy within 6 months after diagnosis, 48 patients (64.0%) improved and 6 patients (8.0%) worsened. The radiological patterns in the patients with ARS-ILD included nonspecific interstitial pneumonia (NSIP) in 46.7% and NSIP with organizing pneumonia overlap in 52.0% of the cases. One-third of the initially improved patients who worsened over the long-term course were assigned to the unstable group. By multivariate logistic analysis, middle lobe traction bronchiectasis was a significant predictive factor for the patients in the unstable group. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Most patients with ARS-ILD receiving anti-inflammatory therapy had improved or remained stable in the first year. However, over the long-term course, some patients worsened despite their initial improvement. Even though the extent of the disease is limited, middle lobe traction bronchiectasis in ARS-ILD may be a useful predictor of poor long-term disease behavior.<\/jats:p>","DOI":"10.1159\/000488358","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T18:31:35Z","timestamp":1526495495000},"page":"210-221","source":"Crossref","is-referenced-by-count":45,"title":["Predictive Factors for the Long-Term Deterioration of Pulmonary Function in Interstitial Lung Disease Associated with Anti-Aminoacyl-tRNA Synthetase Antibodies"],"prefix":"10.1159","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2480-6087","authenticated-orcid":false,"given":"Hideaki","family":"Yamakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideya","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae","family":"Iwasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Otoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Aiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Katano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Shintani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-7911","authenticated-orcid":false,"given":"Satoshi","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akimasa","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Iso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Kuwano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3282f01a8c"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060442"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000440665"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.09.005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.05.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.07.009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.12.014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.069237"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.11.026"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0325-y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00150-2015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098824"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2016.09.006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.02.002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.05.012"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1134392"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161480"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/art.21240"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/art.30513"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev004"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3109\/03009749709065660"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1713-6"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488358","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:52:06Z","timestamp":1745412726000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488358"}},"subtitle":[],"short-title":[],"issued":{"date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