{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:27:22Z","timestamp":1778732842667,"version":"3.51.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Objectives: To measure the density of retinal vessels from digitized fundus photographs in patients with recent stroke and age-matched controls. To investigate whether the parameter retinal vascular density (RVD) served as a quantitative marker for cerebrovascular events. Methods: Digitized fundus photographs of n = 158 subjects with stroke or transient ischemic attack within 1 year at the time of examination and n = 1,250 age-matched controls without any remarkable medical history were examined. Sex, hypertension, and diabetes were considered to be cofactors. Measurement of RVD was performed with a computer-aided image-analyzing program by segmenting automatically all visible retinal vessels and measuring areas of vessels in distinct circles around the optic disk. Results: In controls RVD dwindles with increasing distance from the optic disk. RVD decreased significantly with age (p = 0.000). Stroke patients showed significantly lower values of RVD of \u201315% in comparison to age-matched controls. In old subjects, stroke in combination with hypertension is associated with a significant decreased RVD, and in middle-aged subjects diabetes and stroke are associated with a significant decreased RVD (p = 0.01). Conclusion: Age and stroke are significant risk factors for decreased RVD. Diabetes and arterial hypertension are additional significant risk factors in patients with stroke with respect to RVD.<\/jats:p>","DOI":"10.1159\/000488491","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T17:01:22Z","timestamp":1528304482000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke"],"prefix":"10.1159","volume":"60","author":[{"given":"Andrea","family":"Spr\u00f6dhuber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Wolz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Budai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Laumeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich\u00a0J.","family":"Audebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Michelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.189142"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-016-0222-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.228.229"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu074"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(01)00234-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.1.67"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00395.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06253-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-857941"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90525-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12288"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20574"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/sj\/EYE\/6700100"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12784]"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-1637(02)00064-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294173"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpet.2009.12.007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70131-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000195134.04355.e5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.496091"}],"updated-by":[{"DOI":"10.1159\/000502215","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000}}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/ore\/article-pdf\/60\/1\/1\/4018397\/000488491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/ore\/article-pdf\/60\/1\/1\/4018397\/000488491.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:19:25Z","timestamp":1745410765000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,6,27]]},"published-print":{"date-parts":[[2018,7,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000488491","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.6449687","asserted-by":"subject"},{"id-type":"doi","id":"10.1159\/000502215","asserted-by":"object"}]},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}