{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:24:14Z","timestamp":1762917854354,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs) therapy has been recognized as the standard treatment for patients with non-small cell lung cancer (NSCLC) harboring <i>EGFR<\/i> mutations. However, resistance to EGFR-TKIs has been observed in certain subpopulations of these patients. We aimed to evaluate the impact of smoking history on the efficacy of EGFR-TKIs. <b><i>Methods:<\/i><\/b> The records of patients (<i>n =<\/i> 248) with NSCLC harboring activating <i>EGFR<\/i> mutations who were treated with gefitinib or erlotinib at our institution between March 2010 and June 2016 were retrospectively reviewed, and the treatment outcomes were evaluated. <b><i>Results:<\/i><\/b> The overall response rate and median progression-free survival (PFS) were 59.7% and 10.7 months, respectively. The overall response rate was significantly higher in the ex- and nonsmokers than in the current smokers (64.6 vs. 51.1%, <i>p =<\/i> 0.038). PFS also differed significantly between the current smokers and the ex- and nonsmokers (12.4 vs. 7.4 months, <i>p =<\/i> 0.016). Multivariate analysis identified smoking history as an independent predictor of PFS and overall survival. <b><i>Conclusion:<\/i><\/b><i><\/i> The clinical data obtained in this study provide a valuable rationale for considering smoking history as a predictor of the efficacy of EGFR-TKI in NSCLC patients harboring activating <i>EGFR<\/i> mutations.<\/jats:p>","DOI":"10.1159\/000488594","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T21:01:22Z","timestamp":1524776482000},"page":"109-115","source":"Crossref","is-referenced-by-count":7,"title":["Smoking History as a Predictor of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Cancer Harboring <b><i>EGFR<\/i><\/b> Mutations"],"prefix":"10.1159","volume":"95","author":[{"given":"Noriko","family":"Nishinarita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Igawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kasajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichiro","family":"Kusuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Okuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Mitsufuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Yokoba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiichiro","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Naoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.8033"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040938"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099314"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405220101"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000449024"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000446437"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909530"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70364-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71173-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22220"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-006-0583-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000446438"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000319937"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.04.006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810699"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000458412"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2007.11.008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31828b51d4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0698"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-1029"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(02)00340-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.029"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.024"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27816"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2014.09.008"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31828c3929"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.01.022"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt127"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0285"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70393-X"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:20:14Z","timestamp":1745425214000},"score":1,"resource":{"primary":{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