{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:14:32Z","timestamp":1783448072207,"version":"3.55.0"},"reference-count":37,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":2818,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purpose: To investigate thyroid gland characteristics on &amp;lt;sup&amp;gt;18&amp;lt;\/sup&amp;gt;F-FDG positron emission tomography\/computed tomography (PET\/CT) imaging in patients with neurofibromatosis type 1 (NF1). Subjects and Methods: Thyroid gland characteristics of patients with a clinical diagnosis of NF1 who underwent &amp;lt;sup&amp;gt;18&amp;lt;\/sup&amp;gt;F-FDG PET\/CT imaging for the first time to distinguish benign neurofibroma from malignant peripheral nerve sheath tumor (MPNST) at our institution (n = 69) were compared to PET\/CT imaging of sarcoidosis (n = 25) and early stage lung cancer (T&amp;lt;sub&amp;gt;1&amp;lt;\/sub&amp;gt;N&amp;lt;sub&amp;gt;0&amp;lt;\/sub&amp;gt;M&amp;lt;sub&amp;gt;0&amp;lt;\/sub&amp;gt; tumors, n = 15) patients. Results: Two NF1 patients (3%) showed a diffuse &amp;lt;sup&amp;gt;18&amp;lt;\/sup&amp;gt;F-FDG&amp;lt;sup&amp;gt;&amp;lt;\/sup&amp;gt; uptake in the thyroid gland, 2 patients (3%) had an irregular uptake, and 7 patients (10%) had a focal uptake. Among the sarcoidosis patients, 1 showed a diffuse uptake (4%) and 1 had an irregular uptake (4%). In the early stage lung cancer group, 1 patient showed a diffuse uptake (7%) and 1 had a focal uptake (7%). NF1 patients had larger mean thyroid volume and mean SUV&amp;lt;sub&amp;gt;max&amp;lt;\/sub&amp;gt; compared to sarcoidosis patients but not compared to early stage lung cancer patients. Four NF1 patients were diagnosed with multinodular goiter, 2 patients were diagnosed with benign chronic lymphocytic thyroiditis, 1 patient had metastasis to the thyroid, and 1 patient had medullary thyroid cancer. Conclusion: Even though NF1 patients did not show an increased risk of thyroid incidentaloma on PET\/CT compared to previous studies on non-thyroid cancer patients, the incidence shows that awareness of possible thyroid disease is important.<\/jats:p>","DOI":"10.1159\/000488706","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T17:01:27Z","timestamp":1528218087000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":7,"title":["Thyroid Gland 18F-FDG Uptake in Neurofibromatosis Type 1"],"prefix":"10.1530","volume":"7","author":[{"given":"Zo\u00eb\u00a0Y.G.J.","family":"van\u00a0Lierop","sequence":"first","affiliation":[{"name":"1Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Jentjens","sequence":"additional","affiliation":[{"name":"3Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique\u00a0H.M.E.","family":"Anten","sequence":"additional","affiliation":[{"name":"1Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands"},{"name":"2Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Wierts","sequence":"additional","affiliation":[{"name":"3Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie\u00a0T.","family":"Stumpel","sequence":"additional","affiliation":[{"name":"2Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands"},{"name":"4Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"Havekes","sequence":"additional","affiliation":[{"name":"5Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinus\u00a0J.P.G.","family":"van\u00a0Kroonenburgh","sequence":"additional","affiliation":[{"name":"2Neurofibromatosis Expert Team, Maastricht University Medical Centre, Maastricht, The Netherlands"},{"name":"3Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"2026070712552060300_ref1","unstructured":"Ferner RE, Gutmann DH: International consensus statement on malignant peripheral nerve sheath tumours in neurofibromatosis 1. 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