{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:10:07Z","timestamp":1780445407771,"version":"3.54.1"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2019]]},"abstract":"<b><i>Background and Aims:<\/i><\/b> Vitamin D deficiency is more common in inflammatory bowel disease (IBD) patients than in the general population. However, there are conflicting data about predictive factors of vitamin D deficiency and its potential association with disease activity. The aims of this study were to determine the prevalence and predictive factors of vitamin D deficiency and to evaluate a possible association with disease activity. <b><i>Methods:<\/i><\/b> A prospective observational study was conducted, including patients with IBD from January to July 2016. The Endocrine Society guidelines were considered for defining levels of serum 25-hydroxyvitamin D (25-OH-D) as follows: deficient (&#x3c; 20 ng\/mL, &#x3c; 10 ng\/mL being severe deficiency), insufficient (21\u201329 ng\/mL), and adequate (&#x3e; 30 ng\/mL). <b><i>Results:<\/i><\/b> A total of 152 patients (52% men; 47.2 \u00b1 17.3 years) were included, of whom 70% had Crohn\u2019s disease (CD). Thirty-seven percent of patients were on immunosuppressors and 17% were on biologics. The majority were outpatients (88.2%). Mean 25-OH-D levels were 17.1 \u00b1 8 ng\/mL (CD: 16.7 \u00b1 8 ng\/mL vs. ulcerative colitis: 17.6 \u00b1 7 ng\/mL, <i>p<\/i> = 0.1). Inadequate levels were present in 90.8% of patients (deficiency: 68.4%; insufficiency: 22.4%). A significant negative correlation between 25-OH-D levels and age (<i>r<\/i> = \u20130.2, <i>p<\/i> = 0.04), C-reactive protein (CRP) levels (<i>r<\/i> = \u20130.22, <i>p<\/i> = 0.004), and Harvey-Bradshaw index (HBi) (<i>r<\/i> = \u20130.32, <i>p<\/i> = 0.001) was found. Patients with severe deficiency showed a higher CRP (0.6 vs. 1.4 mg\/dL, <i>p<\/i> = 0.03), erythrocyte sedimentation rate (ESR) (22 vs. 31 mm\/h, <i>p<\/i> = 0.03), and HBi (2 vs. 5, <i>p<\/i> &#x3c; 0.001) and lower hemoglobin (13.6 vs. 12.7 g\/dL, <i>p<\/i> = 0.02). There was no association between vitamin D deficiency and gender, type, extent, and duration of disease, surgery, and other measures of disease activity, such as ESR, hemoglobin (these 2 items except for severe deficiency), fecal calprotectin, or Truelove and Witts classification. <b><i>Conclusions:<\/i><\/b> There is a high prevalence of inadequate levels of vitamin D in IBD patients, particularly deficiency (68.4%). There seems to exist an association between lower levels of vitamin D and higher disease activity, especially in CD.<\/jats:p>","DOI":"10.1159\/000488744","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T21:01:21Z","timestamp":1526331681000},"page":"155-162","source":"Crossref","is-referenced-by-count":12,"title":["Vitamin D Deficiency in a Portuguese Cohort of Patients with Inflammatory Bowel Disease: Prevalence and Relation to Disease Activity"],"prefix":"10.1159","volume":"26","author":[{"given":"Joana\u00a0C.","family":"Branco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3670-5582","authenticated-orcid":false,"given":"Mariana\u00a0F.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Anapaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2643-9359","authenticated-orcid":false,"given":"Lu\u00eds\u00a0Carvalho","family":"Louren\u00e7o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00a0Maria","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina\u00a0Gra\u00e7a","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge\u00a0A.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,5,14]]},"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:21:52Z","timestamp":1745425312000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,5,3]]},"published-print":{"date-parts":[[2019,5,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000488744","archive":["Portico"],"relation":{},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"value":"2341-4545","type":"print"},{"value":"2387-1954","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,14]]}}}