{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:30:22Z","timestamp":1778689822286,"version":"3.51.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; When managing a nonviable pregnancy of unknown location (PUL), a debate has emerged in the literature whether to perform uterine curettage for definitive diagnosis of pregnancy location or administer methotrexate for a presumed ectopic pregnancy. The purpose of this study is to describe the treatment patterns when managing a PUL. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A prospective, anonymous Internet based-electronic survey of PUL case scenarios was administered to a random sample of physicians across the United States. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A total of 214 physicians responded. When presented with a PUL by ultrasound and a \u03b2hCG measurement of 3,270\u00a0mIU\/mL, which is above the discriminatory level, 88.3% (188) would choose an additional \u03b2hCG measurement before recommending any intervention. When presented with a PUL by ultrasound and serial \u03b2hCG measurements demonstrating an inappropriate trend for a viable gestation, 36.5% would offer uterine curettage and 31.3% would offer methotrexate. Resident and private clinicians had a fourfold lower adjusted odds of choosing uterine curettage compared to academic physicians. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Based on our findings, there does not appear to be a consensus regarding the management of a PUL.<\/jats:p>","DOI":"10.1159\/000488760","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T21:01:22Z","timestamp":1528318882000},"page":"552-557","source":"Crossref","is-referenced-by-count":6,"title":["Trends in the Management of Nonviable Pregnancies of Unknown Location in the United States"],"prefix":"10.1159","volume":"83","author":[{"given":"Melissa\u00a0A.","family":"Parks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt\u00a0T.","family":"Barnhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David\u00a0L.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.012"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det450"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.11.038"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000142712.80407.fd"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.12.056"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.09.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.11.021"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms035"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.032"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.033"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del223"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.12.023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)30422-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1302417"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.205.2.9356647"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318278f421"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.06.068"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:22:08Z","timestamp":1745425328000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,11,8]]},"published-print":{"date-parts":[[2018,11,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000488760","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}