{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:12:26Z","timestamp":1771621946999,"version":"3.50.1"},"reference-count":28,"publisher":"S. Karger AG","issue":"9","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Introduction<\/i><\/b>: Younger women are particularly affected by the increase in the incidence of vulvar cancer. The purpose of this study was to investigate how clinical characteristics differ depending on the patient\u00b4s age and what role the age of initial diagnosis plays in the prognosis. <b><i>Patients and<\/i><\/b><b><i>Methods<\/i><\/b>: Included patients were divided into groups aged below or above 50 years. The disease-free survival (DFS) was calculated and a multivariate discriminant analysis was conducted. <b><i>Results<\/i><\/b>: Of the 300 patients, 79 were \u226450 years and 221 were >50 years. The median age was 64 years (19-96 years). There were no differences between the groups regarding lymph node (LN) status and distant metastasis, but T1 tumours were more frequent in patients \u226450 years (77% vs. 62%, p = 0.02). The DFS only differed between the groups when there were no LN metastases. The nodal status was the predominant prognostic factor for the DFS regardless of age. In node-free patients, the 5-year DFS was 49% for the \u226450 years group and 89% for the >50 years group (p = 0.008), whereas there was no difference if a LN was involved. <b><i>Conclusion<\/i><\/b>: In node-free patients, the risk for recurrence is lower for patients older than 50 years.<\/jats:p>","DOI":"10.1159\/000488800","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T21:23:55Z","timestamp":1532467435000},"page":"520-524","source":"Crossref","is-referenced-by-count":15,"title":["The Impact of Age on the Prognosis of Vulvar Cancer"],"prefix":"10.1159","volume":"41","author":[{"given":"Louisa T.","family":"Hami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjoern","family":"Lampe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Mallmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk M.","family":"Forner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S68979"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-103728"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.03.027"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.09.869"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000210268.57527.a1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116270"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.20.1516"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1286271"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2017.1360513"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.11.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00101-V"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.04.004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3932-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.01.014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23446"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.10.029"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30523"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000182"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.05.019"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.881941"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.11.052"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.06.012"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.05.018"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000859"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14918"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju426"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.03.013"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:22:46Z","timestamp":1745425366000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000488800","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"value":"2296-5270","type":"print"},{"value":"2296-5262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}