{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:38:22Z","timestamp":1785188302743,"version":"3.55.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Objectives:<\/i><\/b> The study aimed to evaluate associations of prostatic chronic inflammation (PCI) with prostate cancer (PCA) grade groups by the International Society of Urological Pathology (ISUP). <b><i>Methods:<\/i><\/b> The study evaluated retrospectively 738 cases. The patient population was sampled into 3 groups collecting cases without and with PCA including subjects with lSUP grade group 1 and grade groups 2\u20135. <b><i>Results:<\/i><\/b> PCI was assessed in 185 patients (25.1%) and PCA in 361 patients (48.9%) of whom 188 (25.5%) had ISUP grade and 173 (23.4%) had ISUP groups 2\u20135 tumors. PCI inversely related to ISUP groups (<i>p<\/i> &#x3c; 0.0001). In multivariate analysis, the risk of ISUP grade group 1 PCA compared to negative cases associated positively with age (OR 1.042; <i>p<\/i> = 0.001) but inversely with total prostate volume (TPV; OR 0.965; <i>p<\/i> &#x3c; 0.0001) and PCI (OR 0.314; <i>p<\/i> &#x3c; 0.0001). Intermediate-high grade tumors associated positively with age (OR 1.065; <i>p<\/i> &#x3c; 0.0001), prostate specific antigen (OR 1.167; <i>p<\/i> &#x3c; 0.0001), and abnormal digital rectal examination (OR 2.251; <i>p<\/i> &#x3c; 0.0001) but inversely with TPV (OR 0.921; <i>p<\/i> &#x3c; 0.0001) and PCI (OR 0.106; <i>p<\/i> &#x3c; 0.0001). <b><i>Conclusions:<\/i><\/b> PCI decreased the risk of PCA among ISUP tumor grade groups.<\/jats:p>","DOI":"10.1159\/000488882","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T21:01:18Z","timestamp":1524171678000},"page":"456-462","source":"Crossref","is-referenced-by-count":12,"title":["Inverse Association of Prostatic Chronic Inflammation among Prostate Cancer Tumor Grade Groups: Retrospective Study of 738 Consecutive Cases Elected to a First Random Biopsy 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