{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:55:21Z","timestamp":1780340121013,"version":"3.54.1"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>Signet ring cell carcinoma (SRCC) of the ampulla of Vater is an extremely rare tumor. Our case describes a 45-year-old female presenting with jaundice and pruritus. Computed tomography, endoscopy, and endoscopic retrograde cholangiopancreatography showed a tumor of the ampulla of Vater without distant metastasis. Histological biopsy confirmed a malignant tumor with SRCC characteristics and immunohistochemical staining revealed a mixed type profile (both intestinal and pancreatobiliary characteristics). A pylorus-preserving pancreatoduodenectomy was performed and the patient recovered without complications. Pathology results concluded a pT2N0 ampullary SRCC. SRCC of the ampulla of Vater is known to be highly malignant. After 13 months of follow-up, our patient showed no signs of recurrence.<\/jats:p>","DOI":"10.1159\/000488903","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T21:01:26Z","timestamp":1524862886000},"page":"194-201","source":"Crossref","is-referenced-by-count":5,"title":["Signet Ring Cell Carcinoma of the Ampulla of Vater: A Rare Histopathological Variant"],"prefix":"10.1159","volume":"12","author":[{"given":"Guus\u00a0W.","family":"de\u00a0Klein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joop","family":"van\u00a0Baarlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie\u00a0J.","family":"Mekenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike\u00a0S.L.","family":"Liem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost\u00a0M.","family":"Klaase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200012010-00014"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.10.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.50.10.867"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i40.11428"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2344"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.025"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199807000-00013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-015-9718-z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-017-0287-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2015.05.031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-010-1156-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/970234"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2002.128698"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10595-002-2509-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-007-3534-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318216db94"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.2385"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/402798"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/488903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:23:59Z","timestamp":1745425439000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000488903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,27]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,6,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000488903","archive":["Portico"],"relation":{},"ISSN":["1662-0631"],"issn-type":[{"value":"1662-0631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,27]]}}}