{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:48:44Z","timestamp":1780757324717,"version":"3.54.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervent Neurol"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Introduction:<\/i><\/b> This study assessed the safety and effectiveness of the Pipeline embolization device (PED) for persistent and recurrent aneurysms previously treated with either a vascular reconstruction device (VRD) or a flow diverter (FD). <b><i>Methods:<\/i><\/b> A prospective, IRB-approved database was analyzed for patients treated with PED for aneurysms previously treated with a stent. <b><i>Results:<\/i><\/b> Twenty procedures were performed on 18 patients, 11 with prior FD, 7 with VRD, and 2 previously treated with both. Overall, 15 aneurysms were saccular (75%), and size was 13.5 \u00b1 7.6 mm. Location was internal carotid artery (ICA) in 14 cases (70%) and posterior circulation in 6 cases (30%). Average prior treatments were 1.7. Previously FD cases were re-treated at an average of 18.1 months from most recent treatment. Each case used 1 device, 82% with distal coverage and 82% with proximal coverage of prior stent. Balloon remodeling was performed in 3 cases (27%) and no in-stent thrombosis was observed. Previously VRD stent-coiled cases were re-treated at an average of 87.5 months. These cases used on average 1.9 devices, 89% with distal and 100% proximal coverage. Adjunctive coiling was performed in 1 case (11%), balloon remodeling in 5 cases (56%), and 2 cases (28%) developed thrombosis that resolved with abciximab. Re-VRD cases were longer (59.1 vs. 33.7 min, <i>p<\/i> = 0.02) than re-FD. Angiographic follow-up was available for 16 cases (80%). In re-FD, occlusion was complete in 56% and partial progressive in 33% at 17.1 months digital subtraction angiography. In re-VRD, occlusion was complete in 57% and partial progressive in 27% at 8.1 months. Two complications occurred (10%), including one asymptomatic cervical ICA occlusion and one stent occlusion with associated mortality (5%). Clinical follow-up was 17.8 months on average (range 0.5\u201351.9). <b><i>Conclusions:<\/i><\/b> Salvage flow diversion for previously stented aneurysms is technically challenging but offers good prospects of aneurysm obliteration with acceptable complication rates.<\/jats:p>","DOI":"10.1159\/000489018","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T21:01:31Z","timestamp":1527886891000},"page":"359-369","source":"Crossref","is-referenced-by-count":22,"title":["Pipeline Embolization for Salvage Treatment of Previously Stented Residual and Recurrent Cerebral Aneurysms"],"prefix":"10.1159","volume":"7","author":[{"given":"Matthew\u00a0T.","family":"Bender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chau\u00a0D.","family":"Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica\u00a0K.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0A.","family":"Zarrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick\u00a0M.","family":"Westbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin\u00a0M.","family":"Caplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael\u00a0J.","family":"Tamargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Mei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey\u00a0P.","family":"Colby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander\u00a0L.","family":"Coon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jnis.2011.004911"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.044"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyw014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3171\/2017.11.JNS171738"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082311"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-011-0948-x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011672"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4613"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2012-010299"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011894"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013184"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000456086"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012971"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/159101991001600204"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3171\/2015.7.JNS15582"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000579"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4329"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3171\/2017.3.FOCUS1744"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/1591019916631147"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2012-010612"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3171\/2017.7.JNS171289"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3171\/2015.12.JNS152065"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2336"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3171\/2017.3.JNS17574"}],"container-title":["Interventional 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