{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:29:39Z","timestamp":1747193379029,"version":"3.40.5"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Objective:<\/i><\/b> This study evaluated the performance of a flow cytometry system (LC-1000) in screening cervical precancerous lesions at routine health checkups. <b><i>Study design:<\/i><\/b> In total, 928 health examinees were enrolled at 16 health promotion centers in 13 Korean cities between 2016 and 2017. All participants underwent liquid-based cervical cytology and flow cytometry testing to determine the cell proliferation index (CPIx). <b><i>Results:<\/i><\/b> The positivity rate of the LC-1000 system increased with the severity of the cervical cytology findings (<i>p<\/i> for trend &#x3c; 0.001). When low-grade squamous intraepithelial lesion (LSIL) or higher (including LSIL, high-grade squamous intraepithelial lesion [HSIL], and atypical squamous cells without excluding HSIL [ASC-H]) was defined as gold-standard positivity, the sensitivity, specificity, PPV, and NPV of LC-1000 were 75.3% (95% confidence interval [CI], 66.8\u201383.7), 58.5% (95% CI, 55.2\u201361.9), 18.1% (95% CI, 14.5\u201321.8), and 95.1% [95% CI, 93.2\u201397.0], respectively. The median CPIx increased significantly from normal cytology to HSIL (<i>p<\/i> &#x3c; 0.001). The median CPIx was higher in high-risk human papillomavirus (HR-HPV)-positive cases than in HR-HPV-negative cases (0.23 vs. 0.17, <i>p<\/i> &#x3c; 0.001), while it did not differ between HR-HPV-positive and HR-HPV-negative cases with normal cytology findings (0.16 vs. 0.16, <i>p<\/i> = 0.700). <b><i>Conclusion:<\/i><\/b> The LC-1000 system is potentially useful for screening cervical precancer and cancer, especially when excluding normal or ASC of undetermined significance cases in routinely screened populations.<\/jats:p>","DOI":"10.1159\/000489079","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T21:01:18Z","timestamp":1527627678000},"page":"279-287","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the LC-1000 Flow Cytometry Screening System for Cervical Cancer Screening in Routine Health Checkups"],"prefix":"10.1159","volume":"62","author":[{"given":"Ilyeong","family":"Heo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung-Jung","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-4364","authenticated-orcid":false,"given":"Eun-Hee","family":"Nah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Ik","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1068-607X(00)00032-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1588"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPTGD94EVRSJCG"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01202222"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1309\/6NXC-V9XD-YM87-8FAE"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2017.18.6.1595"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.07.102"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9033.abs"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1689"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn036"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22022"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinmicnews.2014.06.001"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:25:50Z","timestamp":1745425550000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,7,27]]},"published-print":{"date-parts":[[2018,8,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000489079","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2018]]}}}