{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T03:07:09Z","timestamp":1774840029442,"version":"3.50.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Background\/Aims: Early gastric cancer after Helicobacter pylori (Hp) eradication is difficult to demarcate. We used the vessel plus surface classification system (VSCS) to determine whether magnifying endoscopy with narrow-band imaging (ME-NBI) could demarcate differentiated-type early gastric cancers after Hp eradication, and to identify causes of an unclear demarcation line (DL). Methods: Among 100 lesions of differentiated-type early gastric cancer resected endoscopically, 34 lesions in the Hp-eradicated group and 66 in the Hp-infected group were retrospectively compared. Clinicopathological factors and ME-NBI findings, including the presence or absence of the DL, were examined. Histopathologically, histological gastritis, the surface structure at the tumor border, well-differentiated adenocarcinoma with low-grade atypia (tub1-low), and non-neoplastic epithelium (NE) coverage rate on the tumor surface and at the tumor border were evaluated. Results: DL (\u2013) cases were more frequent in the Hp-eradicated group (11.8%, 4\/34) than in the Hp-infected group (1.5%, 1\/66; p &lt; 0.05). The Hp-eradicated group had a higher NE coverage rate than the Hp-infected group (p &lt; 0.05). All DL (\u2013) cases had tub1-low or NE at the tumor border. Conclusion: ME-NBI with VSCS can identify the DL in most patients (88.2%) with differentiated-type early gastric cancer after Hp eradication.<\/jats:p>","DOI":"10.1159\/000489167","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T21:02:03Z","timestamp":1528232523000},"page":"175-184","source":"Crossref","is-referenced-by-count":14,"title":["Usefulness of Demarcation of Differentiated-Type Early Gastric Cancers after Helicobacter pylori Eradication by Magnifying Endoscopy with Narrow-Band Imaging"],"prefix":"10.1159","volume":"98","author":[{"given":"Yoichi","family":"Akazawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Ueyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Komori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3648-5452","authenticated-orcid":false,"given":"Tsutomu","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenshi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Asaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5979-4384","authenticated-orcid":false,"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02459.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04776.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.15"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0347-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i33.11552"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000460245"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000485504"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02360.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0764-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0479-y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214594"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.08.007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-013-0332-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-107068"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/den.12638"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-016-0622-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0041-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.2.251"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12132"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/98\/3\/175\/4027053\/000489167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/98\/3\/175\/4027053\/000489167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:26:47Z","timestamp":1745425607000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,10,4]]},"published-print":{"date-parts":[[2018,10,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000489167","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}