{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:17:01Z","timestamp":1771463821991,"version":"3.50.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, with 57% undergoing definitive and 43% postoperative radiotherapy. Primary tumour sites were oral cavity (21%), oropharynx (26%), hypopharynx (20%), larynx (22%), and others (11%). Staging included 4% stage I, 15% II, 26% III, 48% IVa, and 7% IVb. Radiotherapy was combined with chemotherapy in 64%. Primary endpoint was locoregional control, and secondary endpoints survival and toxicity. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Median follow-up was 20 months, with 11 locoregional recurrences. Three-year disease-free survival was 58% and overall survival 57%. In the multivariate analysis, age under 64 years, no extracapsular extension, postoperative radiotherapy, induction chemotherapy, and non-oral cavity tumour were significant favourable prognostic factors for disease-free-survival. The overall incidence of acute grade \u22653 toxicities were mucositis 32%, pain 11%, xerostomia 7%, dysphagia 53%, radiodermatitis 44%, and osteonecrosis 1%. Late grade \u22653 toxicities were fibrosis 6%, dysphagia 21%, fistula 1%, and skin necrosis 1%. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Intensity-modulated radiation with helical tomotherapy achieved respectable locoregional control and overall survival, with acceptable toxicity, in head and neck cancer patients.<\/jats:p>","DOI":"10.1159\/000489217","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T21:01:29Z","timestamp":1528837289000},"page":"61-68","source":"Crossref","is-referenced-by-count":17,"title":["Locoregional Control and Toxicity in Head and Neck Carcinoma Patients following Helical Tomotherapy-Delivered Intensity-Modulated Radiation Therapy Compared with 3D-CRT Data"],"prefix":"10.1159","volume":"95","author":[{"given":"Olalla","family":"Santa\u00a0Cruz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelagia","family":"Tsoutsou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril\u00a0","family":"Castella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaouthar","family":"Khanfir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Anchisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim\u00a0","family":"Bouayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar\u00a0","family":"Matzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Ozsahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69121-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00438-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.10.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.09.018"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.4498"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.04.014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.7802"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt461"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.12.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.025"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.06.040"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.10.061"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.12.054"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.07.059"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.07.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70290-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.07.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-012-0289-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.05.006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00247-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.09.021"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.07.1708"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:17Z","timestamp":1745425637000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,7,31]]},"published-print":{"date-parts":[[2018,8,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000489217","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}