{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:19:18Z","timestamp":1784420358312,"version":"3.55.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> To evaluate the predictive value of dialysate interleukin-6 (IL-6) representing local subclinical intraperitoneal inflammation for the development of peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients. <b><i>Methods:<\/i><\/b> Stable prevalent CAPD patients were enrolled in this prospective study. IL-6 concentration in the overnight effluent was determined and expressed as the IL-6 appearance rate (IL-6AR). Patients were divided into 2 groups according to the median of IL-6AR and prospectively followed up until the first episode of peritonitis, cessation of PD, or the end of the study (December 30, 2017). The utility of IL-6AR in predicting peritonitis-free survival was analyzed using the Kaplan-Meier and Cox proportional hazards models. <b><i>Results:<\/i><\/b> A total of 149 patients were enrolled, including 72 males (48%) with mean age 52.0 \u00b1 13.6 years and median PD duration 26 (5.9\u201345.5) months. During follow-up, 7,923 patient months were observed and 154 episodes of peritonitis occurred in 82 patients. Previous peritonitis episodes were significantly associated with log dialysate IL-6AR levels (\u03b2 = 0.187 [0.022\u20130.299], <i>p<\/i> = 0.023). Patients in the high IL-6AR group showed a significantly inferior peritonitis-free survival when compared with their counterparts in the low IL-6AR group (48.8 vs. 67.7 months, <i>p<\/i> = 0.026), as well as higher treatment failure percentage of peritonitis (20.3 vs. 9.3%, <i>p<\/i> = 0.049). A multivariate Cox regression showed that high dialysate IL-6AR (hazard ratio [HR] 1.247 [1.052\u20131.478]; <i>p<\/i> = 0.011) and high serum C-reactive protein (HR 1.072 [1.005\u20131.144]; <i>p<\/i> = 0.036) were independent risk factors for inferior peritonitis-free survival. <b><i>Conclusion:<\/i><\/b> This prospective study suggested that the intraperitoneal inflammation marker, dialysate IL-6 level, might be a potential predictor of peritonitis development in patients undergoing PD.<\/jats:p>","DOI":"10.1159\/000489271","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T21:01:33Z","timestamp":1526677293000},"page":"317-324","source":"Crossref","is-referenced-by-count":19,"title":["High Intraperitoneal Interleukin-6 Levels Predict Peritonitis in Peritoneal Dialysis Patients: A Prospective Cohort Study"],"prefix":"10.1159","volume":"47","author":[{"given":"Xiaoxiao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7312-8860","authenticated-orcid":false,"given":"Hao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoqi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2016.00078"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00131"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg027"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00185"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011121135"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01260209"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.16"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-185"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013030314"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70011-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000169445"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.10.008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00910209"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11431210"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/912595"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.430]"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000362622"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/039139889702001104"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2009.00022"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-149"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S1073-4449(98)70030-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/484167"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00151-0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-8"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17129"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000080032"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90105-0"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000015126.83143.B4"}],"container-title":["American 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