{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:12:05Z","timestamp":1787238725802,"version":"build-2736575974"},"reference-count":70,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>The clitoris is a highly complex organ whose structure has only been clarified in recent years through the use of modern imaging techniques. Clitoromegaly is an abnormal enlargement of this organ. It may be congenital or acquired and is usually due to an excess of androgens in fetal life, infancy, or adolescence. Obvious clitoromegaly in individuals with ambiguous genitalia is easily identifiable, whereas borderline conditions can pass unnoticed. Case reports of clitoromegaly with or without clinical or biochemical hyperandrogenism are quite numerous. In these subjects, a comprehensive physical examination and an accurate personal and family history are needed to investigate the enlargement. We reviewed the literature on the conditions that may be involved in the development of clitoromegaly in childhood and adolescence.<\/jats:p>","DOI":"10.1159\/000489385","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T17:01:19Z","timestamp":1527267679000},"page":"163-174","source":"Crossref","is-referenced-by-count":31,"title":["Clitoromegaly in Childhood and Adolescence: Behind One Clinical Sign, a Clinical Sea"],"prefix":"10.1159","volume":"12","author":[{"given":"Maria L.","family":"Iezzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Lasorella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Varriale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Zagaroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Ambrosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Verrotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.7.080505.115715"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200X.2003.01731.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2008.10.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.06.035"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0888"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(94)90255-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198511000-00015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1043943"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201638"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1148\/110.1.35"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2015.12.006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2008.11.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320450618"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-1-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2009.01.066"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1180"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01231.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1111040"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00414-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0426"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000318004"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/ng1629"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsc.2013.11.003"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03298.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.80"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01469.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.098319"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2015.20.4.226"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.320"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.10.034"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.79740"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931201)72:11<3340::AID-CNCR2820721133>3.0.CO;2-Z"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2015.1036399"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.182241"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.7957"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.7.1077"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104017"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.810517.x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-0938-8"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.07.022"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.4.396"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148548"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.4103\/0189-6725.129238"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999638"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000173639.38898.cd"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2011.54.5.224"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-1-3"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/261464"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.4103\/0970-4388.105021"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.1.26"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117660"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.073723"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.7.4057"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80439-1"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.03.008"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30104"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33578"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.291.2830"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.9.623"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi262"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2631"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320550316"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90958.2008"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(67)80244-0"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30058"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/ng0295-165"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-18-6-559"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2013.03.001"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2010.06.003"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw273"}],"container-title":["Sexual Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:29:39Z","timestamp":1745411379000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":70,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,7,26]]},"published-print":{"date-parts":[[2018,7,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000489385","archive":["Portico"],"relation":{},"ISSN":["1661-5425","1661-5433"],"issn-type":[{"value":"1661-5425","type":"print"},{"value":"1661-5433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}