{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:16:52Z","timestamp":1789093012632,"version":"build-2803163510"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> Patients with short stature (SS)\/growth hormone deficiency (GHD) and precocious puberty (PP) undergo brain MRI to evaluate for structural brain abnormalities or pituitary lesions, and pituitary microadenomas are a common finding. Theoretically, a mass effect from these lesions could cause GHD and growth hormone treatment could cause them to enlarge, but they should not cause PP, at least in females. <b><i>Methods:<\/i><\/b> We investigated if pituitary microadenomas cause GHD by comparing their incidence in patients with SS\/GHD to that in females with PP. We performed a retrospective chart review of patients with these disorders who had a brain MRI between 2000 and 2013. <b><i>Results:<\/i><\/b> The incidence of microadenoma was high in both groups, 18.5% for SS (<i>n<\/i> = 346) and 21.1% for PP females (<i>n<\/i> = 194), but did not differ between groups (<i>p<\/i> = 0.46). In patients with microadenomas, repeat imaging showed resolution in 58% (SS, <i>n<\/i> = 33) and 67% (PP females, <i>n<\/i> = 21). Importantly, none of the lesions grew, even in patients treated with growth hormone. <b><i>Conclusions:<\/i><\/b> Pituitary microadenomas are common in children with GHD\/SS and PP, but it does not appear that they are a cause of GHD. They appear to be of limited clinical significance and should not be considered a contraindication to growth hormone therapy.<\/jats:p>","DOI":"10.1159\/000489456","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T21:02:10Z","timestamp":1538082130000},"page":"151-160","source":"Crossref","is-referenced-by-count":16,"title":["Incidence and Outcomes of Pituitary Microadenomas in Children with Short Stature\/Growth Hormone Deficiency"],"prefix":"10.1159","volume":"90","author":[{"given":"Kristina\u00a0M.","family":"Derrick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William\u00a0A.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert\u00a0C.","family":"Gensure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0801"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029829"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2702"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2002.15.2.157"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-10-199405150-00001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59602-4.00012-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1048"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01748.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02107"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0656"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1764"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-010-0241-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1272-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2604"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:30:04Z","timestamp":1745425804000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,11,7]]},"published-print":{"date-parts":[[2018,11,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000489456","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.7139699","asserted-by":"subject"}]},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}