{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:20:19Z","timestamp":1777602019614,"version":"3.51.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Temporary proteinuria post-exercise is common and is caused predominantly by renal haemodynamic alterations. One reason is up-regulation of angiotensin\u00a0II (Ang II) due to the reducing effect of angiotensin-converting enzyme (ACE) inhibitors. However, another, ignored, reason could be the kininase effect of ACE inhibition. This study investigated how ACE inhibition reduces post-exercise proteinuria: by either Ang II up-regulation inhibition or bradykinin elevation due to kininase activity inhibition. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Our study included 10 volunteers, who completed 3 high-intensity exercise protocols involving cycling at 1-week intervals. The first protocol was a control arm, the second evaluated the effect of ACE inhibition and the third examined the effect of angiotensin type 1 receptor blockade. Upon application, both agents reduced systolic and diastolic blood pressure; however, there were no statistically significant \u00addifferences. In addition, total protein, microalbumin and \u00ad\u03b2&lt;sub&gt;2&lt;\/sub&gt;-microglobulin excretion levels in urine specimens were analysed before, 30 min after and 120 min after the exercise protocols. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Total protein levels in urine samples were elevated in all 3 protocols after 30 min of high-intensity exercise, compared to baseline levels. However, both ACE inhibition and angiotensin type 1 receptor blockade suppressed total protein in the 30th min. In each protocol, total protein levels returned to the baseline after 120 min. Urinary microalbumin and \u03b2&lt;sub&gt;2&lt;\/sub&gt;-microglobulin levels during the control protocol were significantly higher 30 min post-exercise; however, only angiotensin type 1 receptor blockade suppressed microalbumin levels. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The results indicated Ang II up-regulation, not bradykinin elevation, plays a role in post-exercise proteinuria.<\/jats:p>","DOI":"10.1159\/000489506","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T21:01:22Z","timestamp":1526590882000},"page":"299-304","source":"Crossref","is-referenced-by-count":5,"title":["The Renin\u2013Angiotensin System, Not the Kinin\u2013Kallikrein System, Affects Post-Exercise Proteinuria"],"prefix":"10.1159","volume":"139","author":[{"given":"G\u00fcnnur","family":"Ko\u00e7er","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiz","family":"Basral\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktay","family":"Kuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dcmit\u00a0Kemal","family":"\u015eent\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03350260088032"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199418060-00006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.6.1818"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/00365599309180438"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000186476"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00994.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00501.2007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-830559"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.145"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/10641969709080809"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199803000-00006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.80.1.62"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(94)90061-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00640673"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00581.2007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000097953"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0888-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.4314\/ovj.v6i2.8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1988.254.2.F277"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1177\/000456329303000106"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s004210050217"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:30:15Z","timestamp":1745425815000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,7,31]]},"published-print":{"date-parts":[[2018,8,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000489506","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}