{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:19:46Z","timestamp":1773404386192,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Esomeprazole is commonly administered with food; however, clinical data to support this practice are lacking. We aimed to determine the effect of postprandial ingestion of esomeprazole on reflux symptoms among patients with gastroesophageal reflux disease (GERD). <b><i>Methods:<\/i><\/b> Consecutive patients with GERD adequately controlled with esomeprazole 40 mg daily, entered a 2-week lead-in period during which esomeprazole was administered 30 min before breakfast. Patients were then randomized to continue preprandial ingestion or to ingest esomeprazole following a standardized meal. Outcomes included GERD frequency and severity indices, GERD-health-related quality of life (GERD-HRQL) questionnaire and Short Form 36 (SF-36). <b><i>Results:<\/i><\/b> Thirty-two patients (17 [53.1%] men, aged 53.5 \u00b1 17.2 years) were included, and 16 (50%) switched to postprandial ingestion of esomeprazole. GERD frequency and severity decreased in both groups (\u03949.0 \u00b1 7.2 vs. \u039410.0 \u00b1 8.1, <i>p<\/i> = 0.29; \u03946.6 \u00b1 6.8 vs. \u039410.2 \u00b1 7.4, <i>p<\/i> = 0.57 in postprandial group vs. controls, for frequency and severity, respectively). GERD-HRQL improved in both study groups to a similar degree (\u039410.7 \u00b1 10.5 vs. \u039410.0 \u00b1 13.8, <i>p<\/i> = 0.97). All SF-36 subscores increased in both groups to a similar degree. In a mixed linear model, there were no differences between the study groups in the changes observed in GERD frequency (<i>p<\/i> = 0.49), severity (<i>p<\/i> = 0.32), and GERD-HRQL (<i>p<\/i> = 0.98) during the study period. <b><i>Conclusion:<\/i><\/b> Switching to postprandial administration of esomeprazole is not associated with deterioration in reflux symptoms among patients with GERD. Esomeprazole seems to remain efficacious when administered after meals.<\/jats:p>","DOI":"10.1159\/000489557","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T21:01:19Z","timestamp":1527109279000},"page":"257-263","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Postprandial Administration of Esomeprazole on Reflux Symptoms in Gastroesophageal Reflux Disease: A Randomized, Controlled Trial"],"prefix":"10.1159","volume":"36","author":[{"given":"Doron","family":"Boltin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Zvidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Raskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hen","family":"Kayless","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemda\u00a0","family":"Schmilovitz-Weiss\u00a0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Gingold-Belfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Niv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram","family":"Dickman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072503"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2016.1230496"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.13.68S.31931"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00829.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2011.01322.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02911.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02531.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.444"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32833ae2be"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.14-41"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-002-0502-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02889.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000441972"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03451.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(98)80004-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03140.x"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:30:22Z","timestamp":1745425822000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,7,11]]},"published-print":{"date-parts":[[2018,7,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000489557","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}