{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:39:54Z","timestamp":1777606794392,"version":"3.51.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To report 2 cases of central retinal artery occlusion (CRAO) who underwent retinal endovascular surgery with injection of tissue plasminogen activator (tPA) into the retinal artery and showed a remarkable improvement in visual acuity and retinal circulation. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Standard 25-G vitrectomy was performed under local anesthesia. Simultaneously, tPA (80,000 units\/mL) solution was injected into the retinal artery of the optic disc for 2\u20133 min using a microneedle. Changes in visual acuity, fundus photography, optical coherence tomography (OCT), fluorescein angiography, and laser speckle flowgraphy (LSFG) results were examined. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Both cases could be treated within 12 h after the onset of CRAO. Case 1 was a 47-year-old woman. Her visual acuity improved from counting fingers before operation to 0.08 logMAR 1 month after the surgery. However, thinning of the retina at the macula was observed by OCT. Case 2 was a 70-year-old man. His visual acuity improved from counting fingers to 0.1 logMAR 2 months after the surgery. Both fluorescein angiography and LSFG showed improvement in retinal circulation after the surgery in case 2. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Retinal endovascular surgery with injection of tPA into the retinal artery was feasible and may be a way to improve visual acuity and retinal circulation when performed in the acute phase of CRAO.<\/jats:p>","DOI":"10.1159\/000489696","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T21:01:31Z","timestamp":1529701291000},"page":"327-332","source":"Crossref","is-referenced-by-count":17,"title":["Retinal Endovascular Surgery with Tissue Plasminogen Activator Injection for Central Retinal Artery Occlusion"],"prefix":"10.1159","volume":"9","author":[{"given":"Yuta","family":"Takata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Miyakoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.2585"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3763-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19747-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01586.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(03)00214-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.03.061"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200509000-00022"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.097642"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34626-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19887"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:32:17Z","timestamp":1745425937000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,22]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,9,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000489696","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.6620360","asserted-by":"subject"}]},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,22]]}}}