{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:57:20Z","timestamp":1792519040856,"version":"4.5.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was to evaluate type and evolution of renal involvement for a period of five years. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 121 SSc patients (100 F, 21 M) with mean age of 54.9 \u00b1 13.8, disease duration of 9 \u00b1 6 years, of which 62 had a diffused form and 59 limited form were enrolled. All patients were screened annually for renal function by laboratory examination, ultrasound and color Doppler ultrasound of renal arteries. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Over the five-year observation period, 6 SRC (3 M, 3 F) occurred, four of which required dialysis. One patient developed ANCA-related proliferative glomerulonephritis and the other one acute tubular necrosis. The remaining 113 patients had a preserved renal function (serum creatinine 0.75 \u00b1 0.24 mg\/dl, GFR 93.8 \u00b1 20 ml\/min, 24h proteinuria 0.20 \u00b1 0.15 g). Doppler indices of intrarenal arterial stiffness increased with progression of capillaroscopic damage and with presence of digital ulcers. A negative correlation was observed between estimated GFR and pulsatile index (p&amp;#x3c; 0,05, r=-0.198), resistive index(p&amp;#x3c; 0,01, r=0.267), S\/D ratio (p&amp;#x3c; 0,01, r=-0.237). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In SSc patients, renal function was normal for 4.1 years despite the presence of increased intrarenal arterial stiffness. SRC was observed in 4.9% of SSc patients. In SSc patients, a periodic follow-up based on clinical and laboratory evaluation, colorDoppler ultrasound and, in some cases, renal biopsy is required to evaluate renal involvement.<\/jats:p>","DOI":"10.1159\/000489740","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T21:01:31Z","timestamp":1526418091000},"page":"682-689","source":"Crossref","is-referenced-by-count":25,"title":["Prognostic Factors of Renal Involvement in Systemic Sclerosis"],"prefix":"10.1159","volume":"43","author":[{"given":"Edoardo","family":"Rosato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-765X","authenticated-orcid":false,"given":"Antonietta","family":"Gigante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biagio","family":"Barbano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u00a0Ludovica","family":"Gasperini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Cianci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Muscaritoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(75)90017-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-017-0630-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.11.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/538589"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310311"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq861"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel310"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.6.592"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000431740.32696.cc"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes049"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2523080351"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90986-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.02.031"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283588dcf"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.05.002"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5414\/CN108580"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22309"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2012.723748"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000442996"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex051"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:32:53Z","timestamp":1745425973000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,6,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000489740","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}