{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:20:53Z","timestamp":1784996453085,"version":"3.55.0"},"reference-count":37,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> The calcium-sensing receptor gene (<i>CASR<\/i>) rs1801725 variant is responsible for a non-conservative amino-acid change (A986S) in the calcium-sensing receptor cytoplasmic tail. We hypothesized that rs1801725 polymorphism might be helpful in understanding Ca-related abnormalities in HD patients. <b><i>Methods:<\/i><\/b> In 1215 subjects (245 on cinacalcet), we determined the associations of rs1801725 with secondary hyperparathyroidism (sHPT)-related laboratory parameters, PTH-decreasing effect of cinacalcet hydrochloride, coronary artery disease (CAD), myocardial infarction (MI), nephrolithiasis-related ESRD, and mortality. <i>CASR<\/i> rs7652589(A&#x3c;G)_rs1801725(G&#x3e;T) haplotypes and rs1801725 epistatic interactions with vitamin D signaling pathway genes were examined for associations with selected phenotypes. <b><i>Results:<\/i><\/b> The rs1801725 variant allele showed an increasing independent effect on plasma PTH (P<sub>corrected<\/sub> = 0.009). <i>CASR<\/i> rs7652589_rs1801725 AT haplotype was associated with 1.7-fold higher frequency of PTH levels over 437 pg\/mL than the reference haplotype GG (P = 0.001). <i>CASR<\/i> rs7652589_rs1801725 AG haplotype was 1.5-fold more frequent in nephrolithiasis-related ESRD than the GG haplotype (P = 0.004). There were no significant associations between rs1801725, CAD, MI, and response to cinacalcet. Variant homozygosity of rs1801725 correlated independently with higher infection-related mortality compared with heterozygosity (HR 7.95, 95%CI 2.15 \u2013 29.37, P = 0.003) and major homozygosity (HR 5.89, 95%CI 1.69 \u2013 20.55, P = 0.040). <i>CASR<\/i> rs1801725 did not show epistatic interactions with vitamin D signaling pathway genes concerning tested associations. <b><i>Conclusion:<\/i><\/b> The variant allele of <i>CASR<\/i> rs1801725 solely and together with the variant allele of rs7652589 increases risk of more advanced sHPT. Homozygosity of the rs1801725 variant allele contributes to infection-related mortality in HD patients.<\/jats:p>","DOI":"10.1159\/000489747","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T21:01:31Z","timestamp":1526418091000},"page":"719-734","source":"Crossref","is-referenced-by-count":9,"title":["The Calcium-Sensing Receptor Gene Polymorphism rs1801725 and Calcium-Related Phenotypes in Hemodialysis Patients"],"prefix":"10.1159","volume":"43","author":[{"given":"Alicja\u00a0E.","family":"Grzegorzewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Bednarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"\u015awiderska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna","family":"Mostowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142\u00a0P.","family":"Jagodzi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs598"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.61.s80.27.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000045681"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/srep35188"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11141016"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200501000-00005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/366575a0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06434-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3502-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450421"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02634.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002156"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016010069"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000451006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001035"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0071"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2143\/ACB.3231"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00589.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh128"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.12.004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.188"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2383216"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btf869"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2004.05.001"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm639"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.5812\/numonthly.42569"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt249"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3109\/00365599.2010.497770"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130790"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159\/000254386"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00138.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119459"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000133041.27682.A2"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.05.007"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i9.2711"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8648"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(93)90438-A"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:32:57Z","timestamp":1745425977000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,6,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000489747","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}