{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:22:47Z","timestamp":1789150967161,"version":"build-2803163510"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background and Aim:<\/i><\/b> Oral administration of cystine and theanine (CT) may modulate antioxidant glutathione (GSH) metabolism, thereby improving outcomes after gut ischemia reperfusion. <b><i>Methods:<\/i><\/b> Experiment 1: Institute of Cancer Research mice (<i>n<\/i> = 35) were assigned to a Vehicle (<i>n<\/i> = 11), a CT140 (<i>n<\/i> = 14), or a CT280 (<i>n<\/i> = 10) group. The CT140 and 280 groups were given CT at respective dosages of 140 and 280 mg\/kg (cystine: theanine = 5: 2) once daily via gavage for 5 days. All mice underwent 75-min occlusion of the superior mesenteric artery (SMA). Survival after reperfusion was observed. Experiment 2: Mice (<i>n<\/i> = 67) were pretreated for 5 days (Vehicle: <i>n<\/i> = 24, CT280: <i>n<\/i> = 20, vehicle\/sham: <i>n<\/i> = 23). The Vehicle and CT280 groups underwent 60-min SMA occlusion. Levels of GSH, the oxidized form of GSH, Glutathione-S-S-Glutathione (GSSG), and GSH-related amino acids (cysteine and glutamic acid) in the small intestine, and plasma cytokine (IL-6, IL-1\u03b2, TNF\u03b1) levels, were evaluated before (0 h), 3, 6, or 9 h after reperfusion. <b><i>Results:<\/i><\/b> Experiment 1: The CT280 group showed significantly better survival than the Vehicle group. Experiment 2: Gut GSSG, cysteine, and glutamic acid levels were higher in the CT280 than in the Vehicle group after reperfusion. Plasma IL-6 and TNF\u03b1 levels rose more rapidly in the CT280 than in the Vehicle group. <b><i>Conclusion:<\/i><\/b> Oral administration of CT improves survival after gut I\/R, possibly through the modulation of the GSH-redox cycle and cytokine responses.<\/jats:p>","DOI":"10.1159\/000489825","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T21:01:36Z","timestamp":1532725296000},"page":"131-137","source":"Crossref","is-referenced-by-count":9,"title":["Cystine and Theanine Improve Survival after Gut Ischemia-Reperfusion"],"prefix":"10.1159","volume":"73","author":[{"given":"Taiki","family":"Miyakuni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Fukatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonari","family":"Ri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Murakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigekazu","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadatoshi","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yasuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,7,27]]},"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/489825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:33:24Z","timestamp":1745426004000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000489825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,9,11]]},"published-print":{"date-parts":[[2018,9,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000489825","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}